2'-Fucosyllactose: benefits, dosage, contraindications
Other name(s)
2'-FL, FUT 2
Scientific name(s)
2'-Fucosyllactose
Family or group:
Carbohydrates
Indications
Rating methodology
EFSA approval.
Child development ✪✪✪✪✪
The use of 2'-Fucosyllactose in infant nutrition is crucial for optimal infant development. By consuming it, babies benefit from a natural prebiotic that promotes the growth of good bacteria in their gut. This can help reduce digestive problems, colic, and intestinal infections in infants. Additionally, it has been demonstrated that 2'-Fucosyllactose also improves infant immune health, thus enhancing their resistance to infections.
Posologie
Oral
1.2 g/L
Powder
Fucosylated oligosaccharides of human milk protect suckling mice from heat-stabile enterotoxin of Escherichia coli
Recent advances on 2'-fucosyllactose: physiological properties, applications, and production approaches
Innate protection conferred by fucosylated oligosaccharides of human milk against diarrhea in breastfed infants
The Role of Two Human Milk Oligosaccharides, 2'-Fucosyllactose and Lacto-N-Neotetraose, in Infant Nutrition
Human milk glycans protect infants against enteric pathogens
Dietary modulation of the human colonic microbiota: updating the concept of prebiotics
Digestive issues ✪✪✪✪✪
It has been reported that 2'-Fucosyllactose can significantly reduce the incidence of diarrhea in breastfed infants. In addition, infants breastfed with milk containing 2-FL have larger populations of bifidobacteria compared to infants fed milk lacking 2-FL. In adults, this prebiotic helps support a healthy and balanced intestinal flora, which improves digestion, nutrient absorption, and strengthens the immune system.
Posologie
Oral
0.75 g
Powder
Fucosylated oligosaccharides of human milk protect suckling mice from heat-stabile enterotoxin of Escherichia coli
Recent advances on 2'-fucosyllactose: physiological properties, applications, and production approaches
Innate protection conferred by fucosylated oligosaccharides of human milk against diarrhea in breastfed infants
The Role of Two Human Milk Oligosaccharides, 2'-Fucosyllactose and Lacto-N-Neotetraose, in Infant Nutrition
Human milk glycans protect infants against enteric pathogens
Dietary modulation of the human colonic microbiota: updating the concept of prebiotics
Intestinal permeability ✪✪✪✪✪
2'-Fucosyllactose (2'-FL) acts on intestinal permeability control mainly in two ways. Firstly, 2'-FL has the ability to inhibit pathogen attachment to the intestinal wall. By binding to pathogen receptors, 2'-FL prevents their adhesion to intestinal epithelial cells, thus reducing the risk of lesions and inflammation. Secondly, 2'-FL stimulates the production of factors that strengthen the intestinal barrier. Bifidobacteria, favored by 2'-FL, can reinforce the intestinal barrier by improving the integrity of tight junctions between intestinal epithelial cells.
Posologie
Oral
0.75 g
Powder
Properties
Digestive effect
2-FL is one of the simplest fucosylated oligosaccharides that meets all criteria and acts as a prebiotic to selectively stimulate the growth of beneficial bacteria. A prebiotic is defined as a non-digestible food ingredient that has a beneficial effect on the host by selectively stimulating the growth and/or activity of one or a limited number of bacteria in the colon, thereby improving host health.
Usages associés
Antimicrobial
Several studies have shown the anti-adhesive and antimicrobial effect of fucosylated oligosaccharides. Indeed, fucosylated oligosaccharides inhibit Campylobacter jejuni adhesion to the H(O) blood group epitope and reduce the risk of infection. a0 2-FL also acts as an antifungal modulator and inhibits Candida albicans adhesion to human oral epithelial cells. Recent studies have shown that higher consumption of a-1-2 fucosylated oligosaccharides results in lower mortality among infants infected or exposed to HIV.
Immunomodulatory
Human milk oligosaccharides modify the infant gut microbial environment. In vitro studies show they directly modulate immune responses. A study involving over 400 infants shows that formulas containing 2-fucosyllactose increase the ratio of activated CD8+ T cells, reduce inflammatory cytokine production, and boost immune development in infants.
Usages associés
Neurological
Research on rats has revealed that oral supplementation with 2'-FL promotes brain development in both young and adult rats. In the 1990s, it was discovered that 2'-FL amplifies long-term potentiation in the hippocampus, a phenomenon characterized by strengthened synaptic strength following high-frequency stimulation. However, further studies are needed to confirm the role of 2'-FL in enhancing the cognitive abilities of breastfed infants.
Usages associés
Safety dosage
Infant: 1.2 g/L
The American Food and Drug Administration has recognized 2'-Fucosyllactose (2'-FL) as safe. In the European Union, 2'-FL is classified as a novel food. The European Food Safety Authority (EFSA) assessed 2'-FL on June 29, 2015, and concluded that 2'-FL is safe for infants (up to one year old) when added to infant formulas, in combination with Lacto-N-neotetraose (LNnT), at concentrations of up to 1.2 g/L of 2'-FL and up to 0.6 g/L of LNnT, following a 2:1 ratio in reconstituted formulas. 2'-FL is also safe for young children (over one year old) when used in toddler formulas, up to 1.2 g/L of 2'-FL, alone or in combination with LNnT up to 0.6 g/L, also in a 2:1 ratio.
Adult: 0.75 g - 2.9 g
It can be safely used without exceeding the recommended daily dose.
Pregnant woman: 0.75 g - 2.9 g
It can be safely used without exceeding the recommended daily dose.
Breastfeeding woman: 0.75 g - 2.9 g
It can be safely used without exceeding the recommended daily dose.
Child: 1.2 g/L
The U.S. Food and Drug Administration has classified 2'-FL as safe. In the European Union, 2'-FL is considered a novel food. The European Food Safety Authority (EFSA) evaluated 2'-FL on June 29, 2015, based on scientific and technical information and reported that: 1 2'-FL is safe for infants (up to one year) when added to infant formula, in combination with LNnT, at concentrations up to 1.2 g/L of 2'-FL and up to 0.6 g/L of LNnT, in a 2:1 ratio in reconstituted formula. 2'-FL is safe for young children (over one year old) when added to young child formula, at concentrations up to 1.2 g/L of 2'-FL (alone or in combination with LNnT at concentrations up to 0.6 g/L, in a 2:1 ratio).
