Hydroxycitric Acid: Benefits, Dosage, Contraindications
Other name(s)
Garcinia
Scientific name(s)
hydroxycitric acid
Family or group:
Phytosubstances
Indications
Rating methodology
EFSA approval.
Sports Performance ✪✪✪✪✪
Preliminary clinical research shows that taking 250 mg of hydroxycitric acid per day for 5 days while engaging in daily training increases time to exhaustion from about 25 minutes to about 45 minutes in previously untrained women. Additional preliminary clinical research shows that taking 250 mg of hydroxycitric acid per day for 5 days increases time to exhaustion compared to placebo in elite athletes.
Posologie
Oral
250 mg
Obesity ✪✪✪✪✪
Preliminary clinical research shows that when taken by overweight and obese adults who exercise and follow a low-calorie diet, a product containing 2800 mg of hydroxycitric acid or the same product plus 2 mg of niacin-bound chromium and 400 mg of gymnema extract daily for 8 weeks reduces body weight and body mass index by about 5 to 6% from baseline. However, other clinical research indicates that taking oral hydroxycitric acid for only 2 weeks does not significantly reduce weight, satiety, fat oxidation, or energy expenditure compared to control in obese individuals.
Posologie
Oral
2800 mg
Synergies
Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss
The effect of (-)-hydroxycitrate on energy intake and satiety in overweight humans
Cancer ✪✪✪✪✪
Cancer cells have an abnormal metabolism that makes them glucose-hungry. They are unable to burn this sugar because the mitochondria function poorly. Thus, the cell ferments and divides rapidly. The goal is to enable the mitochondria to burn sugar derivatives and, therefore, to slow cancer growth. A treatment combining alpha-lipoic acid and hydroxycitrate exists. Alpha-lipoic acid is a cofactor of pyruvate dehydrogenase. This enzyme allows the pyruvate (a glucose derivative) to be burned in the mitochondria. Hydroxycitrate has the property of inhibiting citrate lyase, an enzyme essential for cell wall synthesis, hence its anticancer effect. Daily treatment: - Alpha-lipoic acid: 800 mg morning and 800 mg evening orally. - Hydroxycitrate: 500 mg morning, noon, and evening.
Posologie
Oral
500 mg
Synergies
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer
Metabolic treatment of cancer: intermediate results of a prospective case series
Screening of well-established drugs targeting cancer metabolism: reproducibility of the efficacy of a highly effective drug combination in mice
The long-term survival of a patient with pancreatic cancer with metastases to the liver after treatment with the intravenous alpha-lipoic acid/low-dose naltrexone protocol
Cancer: a Simple and Non-toxic Treatment, Dr. Laurent Schwartz
Tumor regression with a combination of drugs interfering with the tumor metabolism: efficacy of hydroxycitrate, lipoic acid and capsaicin
Adding a combination of hydroxycitrate and lipoic acid (METABLOC™) to chemotherapy improves effectiveness against tumor development: experimental results and case report
Properties
Hypolipidemic
In vitro, hydroxycitric acid (HCA) competitively inhibits adenosine triphosphate (ATP) citrate lyase, which is involved in the conversion of carbohydrates into fats (lipogenesis). This enzyme inhibition prevents the splitting of citrate into oxaloacetate and acetyl-CoA, thus limiting the availability of acetyl-CoA for lipogenesis. By this mechanism, HCA limits the biosynthesis of fatty acids and cholesterol in various tissues. However, human research remains contradictory. Animal research suggests that HCA increases the release and availability of serotonin in the brain, which is involved in appetite control, and boosts hepatic glycogen synthesis, influencing liver glucoreceptors and enhancing satiety.
Usages associés
Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt
Effects of 2-week ingestion of (-)-hydroxycitrate and (-)-hydroxycitrate combined with medium-chain triglycerides on satiety and food intake
Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss
Body weight and abdominal fat gene expression profile in response to a novel hydroxycitric acid-based dietary supplement
Transcriptome of primary adipocytes from obese women in response to a novel hydroxycitric acid-based dietary supplement
Hypoglycemic
Animal research shows that hydroxycitric acid reduces insulin resistance and lowers fasting insulin and glucose levels in diabetic mice. Further animal research indicates hydroxycitric acid decreases glucose absorption in the small intestine tissue and improves glucose tolerance in rats.
Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats
Effect of hydroxycitrate on respiratory quotient, energy expenditure, and glucose tolerance in male rats after a period of restrictive feeding
Anti-inflammatory
Hydroxycitric acid may have anti-inflammatory effects. Animal research shows that hydroxycitric acid reduces the expression of inflammation-related genes and decreases inflammatory markers, including C-reactive protein (CRP) and interleukin-6.
Nephroprotective
In an animal model, hydroxycitric acid reduces calcium oxalate crystals, as well as markers of oxidative stress and renal failure.
Anticancer
In vitro, HCA competitively inhibits the extramitochondrial enzyme adenosine triphosphate (ATP) citrate lyase, which is involved in the conversion of carbohydrates into fats (lipogenesis). According to Dr. Schwartz's book (Cancer, a Simple and Non-toxic Treatment), in cancer, the tumor mitochondria "leak." Citrate exits the mitochondria to the surrounding cytoplasm. Blocking the key enzyme, citrate lyase, with hydroxycitrate is necessary.
Safety dosage
Adults 18 years and older: 250 mg - 2800 mg
Interactions
Médicaments
Antiplatelet/Anticoagulant: mild interaction
Theoretically, hydroxycitric acid (HCA) could increase the risk of bleeding when used with antiplatelet or anticoagulant medications.
Antidiabetic: mild interaction
Theoretically, hydroxycitric acid (HCA) could have additive effects with antidiabetic medications and increase the risk of hypoglycemia.
Precautions
Pregnant women: avoid
Pregnant and breastfeeding women should refrain from taking HCA.
Breastfeeding women: avoid
Pregnant and breastfeeding women should refrain from taking HCA.
