Alpha-GPC: Benefits, Dosage, Contraindications

Alpha-GPC, or alpha-glycerylphosphorylcholine, is a cholinergic compound naturally produced in the body from choline. Specifically, it is a choline-containing phospholipid that plays a significant role in supporting cell membranes and enhancing cognitive functions, as a crucial precursor of acetylcholine. Acetylcholine is a neurotransmitter involved in various functions, such as memory, learning, attention, sleep, mood regulation, and muscle functions. When ingested, Alpha-GPC is quickly absorbed and easily crosses the blood-brain barrier. Once metabolized, it breaks down into choline and glycerol-1-phosphate, essential components for the proper functioning of the nervous system and the maintenance of cellular integrity. In Europe and the United States, Alpha-GPC is primarily marketed as a dietary supplement. It is highly regarded for its nootropic properties, enhancing cognitive abilities such as memory and attention. Although research on healthy humans is limited, Alpha-GPC has shown significant benefits in elderly patients with mild to moderate dementia. Besides its effects on cognition, Alpha-GPC is gaining interest in sports for its potential to increase muscular power. It is also considered an effective supplement to enhance the efficacy of acetylcholinesterase inhibitors, often used in the treatment of Alzheimer's disease. When added to this standard treatment, Alpha-GPC may improve the behavioral and cognitive symptoms of patients.