Activated Charcoal: Benefits, Dosage, Contraindications
Other name(s)
a:0:{}
Scientific name(s)
Carbo vegetabilis
Family or group:
Super Food
Indications
Rating methodology
EFSA approval.
Detoxification ✪✪✪✪✪
Oral intake of activated charcoal appears to be effective when part of the standard treatment for certain acute poisonings. Single doses of activated charcoal, from 25 to 100 g in adults (10 to 50 g in children, depending on age), are effective in preventing the absorption of certain drugs if taken within an hour of ingestion.
Posologie
Pharmacokinetics of digoxin cross-reacting substances in patients with acute yellow Oleander (Thevetia peruviana) poisoning, including the effect of activated charcoal
Dose-dependent adsorptive capacity of activated charcoal for gastrointestinal decontamination of a simulated paracetamol overdose in human volunteers
Influence of activated charcoal on the pharmacokinetics and the clinical features of carbamazepine poisoning
Effect of activated charcoal on apixaban pharmacokinetics in healthy subjects
The role of activated charcoal and gastric emptying in gastrointestinal decontamination: a state-of-the-art review
Effect of delayed activated charcoal on acetaminophen concentration after simulated overdose of oxycodone and acetaminophen
Activated Charcoal and Bicarbonate for Aspirin Toxicity: a Retrospective Series
Interventions for paracetamol (acetaminophen) overdose
The effect of activated charcoal on drug exposure following intravenous administration: A meta-analysis
Effect of activated charcoal in reducing paracetamol absorption at a supra-therapeutic dose
Position paper: Single-dose activated charcoal
Diarrhea ✪✪✪✪✪
Preliminary clinical research conducted in children treated with irinotecan (chemotherapy) shows that taking 250 mg of activated charcoal the day before the first infusion, and then every 8 hours until the end of the cycle, reduces the risk of diarrhea by 60% compared to no treatment. Activated charcoal also appears to reduce the risk of severe diarrhea by 92% and the discontinuation of chemotherapy by 87% among these patients.
Posologie
Digestive Disorders ✪✪✪✪✪
A preliminary clinical study conducted in adults with functional dyspepsia shows that taking a specific combination containing 280 mg of activated charcoal, 90 mg of simethicone (medication), and 180 mg of magnesium oxide three times a day for a month reduces the symptoms of dyspepsia, such as postprandial fullness, epigastric pain, and abdominal bloating, compared to placebo.
Posologie
Efficacy of an activated charcoal-simethicone combination in dyspeptic syndrome: results of a randomized prospective study in general practice
Flatulence ✪✪✪✪✪
Preliminary clinical research shows that taking 582 mg of activated charcoal after a meal significantly reduces the incidence of flatulence compared to placebo. On average, subjects taking activated charcoal reported fewer than 3 episodes of flatulence over 8 hours, compared to more than 14 episodes in those taking the placebo. However, other preliminary clinical research shows that taking 520 mg of activated charcoal at breakfast, lunch, dinner, and bedtime for 7 days does not significantly reduce excessive gas or the total number of flatulence episodes compared to baseline values.
Posologie
Failure of activated charcoal to reduce the release of gases produced by the colonic flora
Effects of orally administered activated charcoal on intestinal gas
Efficacy of an activated charcoal-simethicone combination in dyspeptic syndrome: results of a randomized prospective study in general practice
Properties
Digestive Effect
Activated charcoal is capable of absorbing many medications, and it has been demonstrated that it absorbs gases, suggesting it could play a role in reducing flatulence after gas-producing meals. Preliminary clinical evidence suggests that activated charcoal decreases bile acid levels in pregnant patients with cholestasis (the serum bile acid level is associated with cholestasis symptoms).
Usages associés
Purifying
Activated charcoal is widely recognized for its effectiveness in reducing absorption of most common toxic ingestions. Activated charcoal adsorbs many medications, which increases clearance and decreases the elimination half-life. It binds unabsorbed drugs in the gastrointestinal tract. It also binds drugs that diffuse or are transported from the circulation to the intestine, interrupting the enterohepatic circulation of drugs. By this latter mechanism, it can reduce exposure to intravenous medications, including amiodarone, azithromycin, acetaminophen, aspirin, ceftriaxone, doxycycline, lorazepam, methotrexate, metronidazole, morphine, phenytoin, and valproate.
Usages associés
Hypocholesterolemic
Activated charcoal is believed to decrease serum cholesterol levels by interfering with the enterohepatic circulation of bile acids. Cholesterol is necessary for the production of bile acids and is used in greater quantities when bile acid synthesis is increased to normalize levels.
Safety dosage
Adult: 500 mg - 10,000 mg
Activated charcoal is administered in single doses up to 100 g. Lower doses, up to 3.6 grams per day, have been used for up to 3 years. When taking activated charcoal, stools turn dark in color.
Interactions
Médicaments
Oral Contraceptives: Moderate Interaction
Activated charcoal, taken at a dose of 5 g four times a day for 3 days, can bind to oral contraceptives and reduce their absorption, thus limiting their effectiveness and increasing the risk of contraceptive failure. However, some clinical research shows that the risk of this interaction is minimal when activated charcoal is taken either 3 hours after or at least 12 hours before oral contraceptives.
Oral Medications: Strong Interaction
Activated charcoal adsorbs various drugs and can reduce their absorption and/or half-life. Examples of affected medications include: acetaminophen, aminophylline, amiodarone, atenolol, carbamazepine, dapsone, digoxin, disopyramide, fluoxetine, indomethacin, moxifloxacin, nadolol, phenytoin, phenobarbital, piroxicam, quinine, sotalol, theophylline, tricyclic antidepressants, valproate, verapamil, hypertension medications, rheumatism medications. Avoid co-administration.
Precautions
Breastfeeding Women: Use with caution
Charcoal has been used safely orally and short-term.
Pregnant Women: Use with caution
Activated charcoal, 50 g three times a day for 8 days, has been used with apparent safety during pregnancy.
Contraindications
Intestinal Blockage: Forbidden
Use of activated charcoal is contraindicated in cases of intestinal blockage.