Fireweed: Benefits, Dosage, Contraindications

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Fireweed is a perennial flowering plant found in cold and northern climates, growing up to 1 meter tall. It prefers moist sands, growing along paths and near water, up to 2000m in altitude. The leaves are long and thin. The pink or purple flowers are grouped in clusters along the downward-curved stem. They bloom from June to September. The aerial parts of fireweed are used for their medicinal properties. Fireweed contains flavonoids (myricetin, quercetin), oenotheins (A and mainly B), phytosterols, tannins, mucilage, vitamin C, and beta-carotene. Fireweed is known for its effects on the prostate, particularly in cases of benign prostatic hyperplasia.

Other name(s) 

St. Anthony's Herb, Spike Willowherb

Scientific name(s)

Epilobium angustifolium, Chamaenerion angustifolium

Family or group: 

Plants

Active ingredients:

Myricetin

Quercetin

Tannins

Vitamin C

Beta Carotene

Mucilage


Indications

Rating methodology

EFSA approval.

Several clinical trials (> 2) randomized controlled with double blind, including a significant number of patients (>100) with consistently positive outcomes for the indication.
Several clinical trials (> 2) randomized controlled with double blind, and including a significant number of patients (>100) with positive outcomes for the indication.
One or more randomized studies or multiple cohorts or epidemiological studies with positive outcomes for the indication.
Clinical studies exist but are uncontrolled, with conclusions that may be positive or contradictory.
Lack of clinical studies to date that can demonstrate the indication.


Benign prostatic hyperplasia
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Fireweed is traditionally used to improve urinary symptoms of benign prostatic hyperplasia (BPH) including prostatitis. Preliminary clinical studies on patients with benign prostatic hyperplasia (BPH) have examined the effect of fireweed. In one study, daily intake of 500 mg of standardized fireweed extract containing at least 15% oenothein B for 6 months reduced post-void residual volume and nighttime urinary frequency, thus improving prostate-specific scores, but without altering prostate volume. Another study examined the efficacy of a supplement containing fireweed and other extracts (Fluxonorm®) on BPH for 30 days, observing an improvement in several symptoms, including maximal urinary flow rate. These results are encouraging and confirm the traditional use.

Posologie

posologieOral: aerial parts, flowering tops

posologie500 - 2000 mg

formulationinfusion, standardized extract


Acne
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The main active components of fireweed include polyphenols, flavonoids, tannins, and other bioactive substances. These compounds provide beneficial effects for the skin, notably by combating oxidative stress, reducing inflammation, and promoting wound healing. Research suggests that fireweed could be a useful component in cosmetic and dermatological product formulations for treating various skin conditions including acne.

Posologie

posologieTopical, oral: aerial parts, flowering tops

posologie1.5 g

formulationinfusion, cream


Properties


Anti-androgenic

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Laboratory research suggests that fireweed extracts and components may have beneficial effects on the prostate, possibly by down-regulating androgen production, suppressing NF-kB expression, and mitigating inflammatory and oxidative stress in prostate tissue.

Usages associés

Benign prostatic hyperplasia

Anti-inflammatory

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Oenothein B inhibits the activation of inflammatory cells and the production of inflammatory molecules.

Usages associés

Benign prostatic hyperplasia

Anticancer

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Oenothein B inhibits endopeptidase, thus preventing cell proliferation, and triggers apoptosis of tumor cells.

Usages associés

Benign prostatic hyperplasia

Antimicrobial

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Fireweed extract has antibacterial and antifungal effects in vitro. Oenothein B, its constituent, has shown inhibitory effects against Helicobacter pylori and Staphylococcus aureus, as well as against certain fungi species (Candida albicans). Fireweed extract acts on P.acnes and could therefore be of interest in acne treatment.

Usages associés

Acne


Safety dosage

Adult from 18 years: 500 mg - 1500 mg (infusion, dry extract)

In infusion: 1 teaspoon (1 - 2 g) per 250 ml of boiling water for 15 minutes; to be consumed 3 times a day. Standardized extracts containing 15% oenothein B have also been used at a dosage of 500 mg per day.


Precautions

Pregnant woman: avoid

No reliable information on the use of fireweed in pregnant women.

Breastfeeding woman: avoid

No reliable information on the use of fireweed in breastfeeding women.