Raspberry Bush: benefits, dosage, contraindications

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The raspberry bush is a shrub ranging from 1 to 2 meters; its blue-green stems have fine reddish thorns, and its leaves are a deep green on top and felted white underneath. Its white flowers bloom from May to July, later producing velvety, sweet, and fragrant red fruits: raspberries. The raspberry bush originates in temperate Europe and Asia, is cultivated, but can also be found in the wild in forests and at altitudes up to 2000 meters. The parts used for therapeutic purposes are the fruits and leaves. Raspberries contain anthocyanidins (responsible for the red color), ellagitannins, flavonols such as quercetin and kaempferol, catechins, and phenolic acids. Other notable components include ascorbic acid (vitamin C), beta carotene, glutathione, vitamin E, and ketones, which are popular for their supposed effect on weight loss. Raspberry leaves are also rich in flavonols like quercetin and kaempferol, and in ellagic acid. Traditionally, the leaf of the raspberry bush is used for gastrointestinal issues, including diarrhea and mouth and throat inflammations. The raspberry bush is also known as an undisputed remedy for women. The leaves are used as an antispasmodic in menstrual disorders and may facilitate childbirth.

Other name(s) 

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Scientific name(s)

Rubus idaeus

Family or group: 

Plants

Active ingredients:

Ellagic acid

Anthocyanins


Indications

Rating methodology

EFSA approval.

Several clinical trials (> 2) randomized controlled with double blind, including a significant number of patients (>100) with consistently positive outcomes for the indication.
Several clinical trials (> 2) randomized controlled with double blind, and including a significant number of patients (>100) with positive outcomes for the indication.
One or more randomized studies or multiple cohorts or epidemiological studies with positive outcomes for the indication.
Clinical studies exist but are uncontrolled, with conclusions that may be positive or contradictory.
Lack of clinical studies to date that can demonstrate the indication.


Wrinkles
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Clinical research conducted on women aged 30 to 65 years shows that the application of a liquid containing raspberry leaf cell culture extract, 20% vitamin C, and 1% vitamin E on the face every night for 8 weeks improves skin color, elasticity, radiance, softness, and the appearance of wrinkles.

Posologie

posologieTopical: leaf

formulationlotion, liquid extract


Dysmenorrhea
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The EMA indicates that Raspberry leaves are used for the symptomatic relief of minor spasms associated with periods. In gemmotherapy, raspberry buds are very specific for painful periods due to their muscle relaxing action.

Posologie

posologieOral: buds, leaf

posologie300 - 900 mg

formulationinfusion, gemmotherapy, dry extract


Menopause
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Raspberry buds, thanks to their estrogenic action, stimulate the ovaries and may help reduce hot flashes.

Posologie

posologieOral: buds

formulationgemmotherapy


Synergies


Pregnancy
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Raspberry leaf tea is used during pregnancy, particularly to aid the childbirth process. Clinical research shows that daily intake of 2.4 g of raspberry leaves, from the 32nd week of gestation until delivery, does not reduce the need for analgesics during the perinatal period compared to a placebo.

Posologie

posologieOral: leaf

posologie1.4 g

formulationinfusion, dry extract


Properties


Estrogenic Action

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Raspberry leaf may have estrogenic effects. In an animal model, raspberry leaf seems to increase the serum activity of ceruloplasmin oxidase, which is a measure of estrogenic activity in the liver.

Usages associés

Menopause

Antioxidant

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Raspberry fruits and leaves seem to have antioxidant effects according to laboratory research. Known antioxidant constituents include anthocyanins, ellagic acid, and other polyphenols.

Usages associés

Wrinkles

Antispasmodic

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The effects of raspberry leaf on smooth muscles, such as the uterus, seem to vary. Different components of raspberry leaf appear to stimulate or contract the smooth muscle of the uterus. Clinically, the red raspberry leaf may have stimulating or spasmolytic effects. It has been found that these effects could depend on the dose and tissues. For instance, at a low dose, raspberry leaf could cause increased contraction, while at a higher dose, it may have spasmolytic effects and decrease contraction. Similarly, it can decrease tonic tissue contraction and increase relaxed tissue contraction.

Usages associés

Dysmenorrhea, Pregnancy

Anti-inflammatory

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Raspberry extracts inhibit cyclooxygenase-2 (COX-2) and lipoxygenase enzymes in vitro, suggesting potential anti-inflammatory activity. Another study showed that raspberry supplementation activates AMP-activated protein kinase (AMPK) α1, leading to reduced lipid accumulation in skeletal muscle and decreased inflammatory response. This suggests that raspberries may play a role in reducing obesity-related inflammation and improving insulin sensitivity.

Usages associés

ENT Infections, Diarrhea

Antibacterial

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Laboratory research suggests that raspberry and some of its components may have antibacterial effects. Its components have been shown to inhibit the growth of various pathogenic intestinal bacteria such as Campylobacter, Salmonella, Shigella, and Escherichia coli, likely by disrupting the outer membrane of the bacteria.

Usages associés

ENT Infections, Diarrhea


Safety dosage

Adults from 18 years: 339 mg - 900 mg (dry extract)

Dry extract: 113-226 mg, up to 3 to 4 times a day to be taken after meals. Decoction: Crushed plant material for the preparation of infusions for oro-mucosal use: 1.5 to 8 g of the crushed plant material in 150 ml of boiling water, 3 times a day, to be used as a gargle.


Interactions

Médicaments

Antiplatelet/Anticoagulant: minor interaction

In vitro research suggests that raspberry leaf extract has antiplatelet activity and might enhance the effects of antiplatelet medications. Among anticoagulant agents, we find, for example, heparin and warfarin.

Insulin: mild interaction

Raspberry leaf may reduce glucose levels in patients treated with insulin. In a case report (Raspberry Leaf and Hypoglycemia in Gestational Diabetes Mellitus), a 38-year-old woman with gestational diabetes, whose blood sugar was controlled through medical nutrition therapy and insulin, developed hypoglycemia after consuming two servings of raspberry leaf tea per day for 3 days starting from the 32nd week of gestation. The patient had to reduce her insulin doses.


Precautions

Pregnant woman: use with caution

Raspberry leaf is used by nurses and midwives to aid childbirth. There is evidence that raspberry leaf, in doses up to 2.4 g per day, from the 32nd week of pregnancy until delivery, can be used safely.

Breastfeeding woman: avoid

Safety during breastfeeding has not been established. In the absence of sufficient data, use during breastfeeding is not recommended.