L-Cysteine: Benefits, Dosage, Contraindications

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L-Cysteine is a semi-essential amino acid used in protein synthesis. Although the body can produce it from the amino acid methionine, L-Cysteine plays several key roles supporting overall health. Its side chain contains sulfur, crucial for forming disulfide bonds that contribute to protein structure stabilization. It is important not to confuse L-Cysteine with N-acetylcysteine (NAC), as although they are related, their uses and benefits are slightly different. Beyond its contribution to protein structure, L-Cysteine is involved in synthesizing several vital compounds, including glutathione, a powerful antioxidant that protects cells against damage from free radicals and toxins. It also participates in the production of taurine, sulfate, and coenzyme A, essential for proper metabolic functioning and cardiovascular health. Naturally found in certain foods like soy, meats, or nuts, the need for L-Cysteine intake is generally low due to its endogenous synthesis. However, it is often used as a supplement for its antioxidant effects and to support glutathione production, particularly in situations where the body is subjected to increased oxidative stress, such as during chronic illnesses or post-recovery from intense physical exertion. While L-Cysteine is explored for its potential therapeutic effects in various conditions such as addictions or the beauty of appendages, it is important to note that scientific evidence regarding its effectiveness in these areas remains limited.

Other name(s) 

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Amino Acids


Indications

Rating methodology

EFSA approval.

Several clinical trials (> 2) randomized controlled with double blind, including a significant number of patients (>100) with consistently positive outcomes for the indication.
Several clinical trials (> 2) randomized controlled with double blind, and including a significant number of patients (>100) with positive outcomes for the indication.
One or more randomized studies or multiple cohorts or epidemiological studies with positive outcomes for the indication.
Clinical studies exist but are uncontrolled, with conclusions that may be positive or contradictory.
Lack of clinical studies to date that can demonstrate the indication.


Hair Beauty, Skin Healing
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L-Cysteine is consumed for its benefits on skin and hair beauty. In cosmetics, L-Cysteine is incorporated into supplements for its ability to promote scalp health and hair strength, as it is essential for keratin synthesis, a protein that strengthens hair. L-Cysteine helps reduce hair loss and improve hair texture. For the skin, it supports collagen production, enhancing skin elasticity and texture. Its antioxidant properties combat free radical damage, promoting healthy skin.

Posologie

posologieOral

posologie500 mg


Smoking Cessation
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Preliminary clinical studies have shown that using a slow-release tablet containing 3 mg of L-Cysteine with each cigarette for 6 months does not increase smoking cessation chances compared to a placebo. A more qualitative study conducted by the same research group showed that using this tablet increases smoking cessation chances by about 51% compared to a placebo.

Posologie

posologieOral

posologie3 mg


Skin Health
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A randomized controlled study evaluated the effect of L-Glutathione and L-Cysteine supplementation on skin lightening in 124 women aged 30 to 50 with at least one dark spot on the face. The results showed that the combination of L-Cysteine and L-Glutathione lightened the skin on the cheeks and lower forearm. No effect was observed with the placebo.

Posologie

posologieOral

posologie500 mg


Alcoholism
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A small clinical study showed that an immediate-release product containing L-Cysteine (1200 mg) in combination with other ingredients reduced hangover symptoms like nausea, headaches, stress, and anxiety modestly when taken six times between 7 PM and midnight in conjunction with alcohol (1.5 g/kg over 3 hours), compared to a placebo. However, other researchers have questioned the validity of the statistical methods used in this study and suggest that not all noted results were statistically significant.

Posologie

posologieOral

posologie1200 mg


Properties


Antioxidant

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L-Cysteine, a precursor of glutathione, methionine, and taurine, plays a key role for its antioxidant effects. In humans, L-Cysteine intake improved antioxidant status after athletic performance. In animal studies, L-Cysteine modestly reduced levels of certain free radicals and oxidative markers in brain tissue and increased antioxidant activity. It also slightly increased the activities of the antioxidant enzymes catalase and glutathione reductase, although it had no effect on other oxidation markers.


Neurological

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Acting as a neuromodulator, L-Cysteine is essential for glutathione synthesis, playing a role in redox balance. In laboratory studies, it antagonizes GABA-alpha receptors. Additionally, L-Cysteine has been studied for alcohol use disorder. A reduction in the motivation to self-administer ethanol was found in animal models. However, neurotoxic effects have been observed, possibly due to the formation of L-Cysteine metabolites.

Usages associés

Smoking Cessation, Alcoholism


Safety dosage

Adult: 500 mg - 1200 mg

There is no typical dosage. Dosages used in studies range from 500 mg to 1200 mg.