Manganese: Benefits, Dosage, Contraindications
Other name(s)
Mn
Scientific name(s)
manganese
Family or group:
Minerals and Trace Elements
Indications
Rating methodology
EFSA approval.
Manganese Deficiency ✪✪✪✪✪
Manganese deficiency is rare. It manifests as growth retardation, skin and appendage damage (dermatitis, hair pigmentation disorders), decreased blood cholesterol, or even reproductive function impairment. The recommended intake is 2 to 5 mg per day. The former Afssa (French Agency for Food Safety, now Anses) defined a safety limit of 10 mg per day, never to be exceeded.
Posologie
Oral route
2 - 10 mg
Premenstrual Syndrome ✪✪✪✪✪
Clinical research shows that taking 1.0 mg or 5.6 mg of manganese daily in combination with 587 mg or 1336 mg of calcium per day for about 24 weeks improves premenstrual syndrome symptoms, including pain, anxiety, irritability, mood swings. However, it is unclear if this benefit is due to calcium, manganese, or their combination.
Posologie
Oral route
1 - 5.6 mg
24 - weeks
Synergies
Osteoarthritis ✪✪✪✪✪
Taking a specific product containing 228 to 304 mg of manganese ascorbate (about 31-41 mg of elemental manganese), glucosamine hydrochloride (1500 to 2000 mg), and chondroitin sulfate (1200 to 1600 mg) orally per day for 4 months improves pain and quality of life in patients with knee and lumbar spine osteoarthritis.
Posologie
Oral route
228 - 304 mg
4 - months
manganese ascorbate
Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis.
Osteoporosis ✪✪✪✪✪
Taking 5 mg per day of manganese orally in combination with 1000 mg of elemental calcium, 15 mg of zinc, and 2.5 mg of copper over 2 years helps reduce vertebral bone loss in postmenopausal women. On the other hand, taking orally a specific product containing 1.8 mg of manganese, 600 mg of calcium, 200 IU of vitamin D (cholecalciferol), 40 mg of magnesium, 7.5 mg of zinc, 1 mg of copper, and 250 mcg of boron, twice per day for one year, improves bone density in women suffering from osteopenia.
Posologie
Oral route
1.8 - 5 mg
2 - years
Properties
Essential
Manganese is an essential nutrient that acts as a cofactor in several metabolic and enzymatic reactions. Manganese is involved in the metabolism of amino acids, cholesterol, and carbohydrates, normal cell growth, the generation of immune response, bone formation, and glucose regulation. Manganese is a component of an antioxidant enzyme known as superoxide dismutase (SOD), specifically a variant known as manganese superoxide dismutase (MnSOD). Other enzymes that manganese is a known component of include pyruvate carboxylase and glutamine synthetase located in the cytoplasm of glial cells where it converts glutamate (neurotransmitter) into glutamine. European health authorities (EFSA, European Food Safety Authority, and the European Commission) have estimated that products containing manganese may claim to contribute to: normal energy metabolism, the maintenance of normal bones, the maintenance of normal connective tissue formation, and the protection of cells against free radicals (antioxidant effect), only if these products contain at least 0.3 mg of manganese per 100 g, 100 ml, or per package if the product only contains one portion.
Usages associés
Antioxidant
Manganese plays a primary role in the body as a component of an antioxidant enzyme known as superoxide dismutase (SOD), specifically a variant known as manganese superoxide dismutase (MnSOD).
Bone Density
Researchers believe that manganese might play a role in osteoporosis. In fact, decreased plasma concentrations of manganese have been reported in osteoporotic women. Moreover, bone mineral density improved when trace elements, including manganese, were included with calcium in their diet or supplements.
Usages associés
Safety dosage
Adult from 18 years: 3 mg
Infant from 7 to 11 months: 0.5 mg
Child from 1 to 3 years: 0.5 mg
Child from 4 to 6 years: 1 mg
Child from 7 to 10 years: 1.5 mg
Child from 11 to 14 years: 2 mg
Child from 15 to 17 years: 3 mg
Interactions
Médicaments
Antipsychotics: moderate interaction
Hallucinations and behavioral changes have been reported in a patient with liver disease taking haloperidol and manganese. It is believed that the combination of manganese with haloperidol, phenothiazines, or other antipsychotic drugs can increase the risk of manganese toxicity in some patients.
Quinolones: moderate interaction
Theoretically, manganese could reduce the absorption of quinolones, which include ciprofloxacin (Cipro), levofloxacin (Levaquin), gatifloxacin (Tequin), sparfloxacin (Zagam)...
Tetracyclines: moderate interaction
Theoretically, manganese could reduce the absorption of tetracyclines.
Plantes ou autres actifs
Manganese: weak interaction
The concurrent administration of calcium and manganese may decrease the absorption of the latter.
Manganese: weak interaction
The co-administration of iron and manganese decreases the absorption of the latter.
Manganese: weak interaction
The co-administration of zinc and manganese increases the absorption of the latter.
Precautions
Pregnant woman from 18 years: use with caution
Breastfeeding woman from 18 years: use with caution
Liver disorders: use with caution
Chronic liver disease can lead to manganese accumulation and toxicity.
