NADH: benefits, dosage, contraindications
Other name(s)
Coenzyme 1
Scientific name(s)
Nicotinamide Adenine Dinucleotide Hydrate
Family or group:
Pseudo-vitamins
Indications
Rating methodology
EFSA approval.
Fatigue ✪✪✪✪✪
Chronic fatigue syndrome is a condition characterized by intense and persistent fatigue, affecting various body systems. Research suggests that NADH may be beneficial in treating chronic fatigue syndrome due to its role in cellular energy production. A study showed that NADH supplementation at 10 mg per day for 4 weeks improved symptoms in 31% of participants, with continued beneficial effects after 6 months of treatment. Other studies indicate that NADH, often combined with coenzyme Q10, can significantly reduce fatigue and improve quality of life and sleep in patients with chronic fatigue syndrome.
Posologie
Oral
10 mg
6 - months
Synergies
Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial
Comparison of oral nicotinamide adenine dinucleotide (NADH) versus conventional therapy for chronic fatigue syndrome.
Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome?
Parkinson's disease ✪✪✪✪✪
Parkinson's disease, marked by tremors, stiffness, and immobility, has seen promising NADH applications. Clinical studies on NADH show varied results: a small double-blind study showed no significant improvement with NADH administered intravenously and intramuscularly. However, open-label studies report symptom improvements in some patients, with a reduction in disability and better response to the drug levodopa. These results, while encouraging, require further research to confirm NADH's effectiveness in treating Parkinson's.
Posologie
Intravenous, oral
5 - 10 mg
Parenteral application of NADH in Parkinson's disease: clinical improvement partially due to stimulation of endogenous levodopa biosynthesis
Treatment of Parkinson's disease with NADH
Sports performance ✪✪✪✪✪
NADH could be beneficial for sports performance in several studies. For example, observational studies of high-level cyclists who consumed 10 mg of NADH daily for a month showed a notable improvement in oxygen consumption and a reduction in blood lactate levels, leading to a decrease in reaction time. In another independent study conducted in Germany, athletes who took 30 mg of NADH per day for four weeks experienced better oxygen use and a significant reduction in blood lactate after aerobic exercise. These effects are attributed to the improved bioavailability of ATP and nitric oxide in cells, thus facilitating greater endurance and better overall performance.
Posologie
Oral
10 - 20 mg
1 - month
Properties
Bioenergetic
NADH is an essential intermediate in cellular processes that generate energy from glucose in the form of ATP. Higher NADH intake in cells leads to more ATP. This means the cell has more energy at its disposal, functions better, and lives longer.
Usages associés
Neurological
NADH stimulates dopamine production in nerve cells, significantly increasing its levels in the brain and blood, which positively impacts libido, appetite, and cell regeneration. Studies confirm a dopamine increase of up to 50% in athletes after supplementation with 5 mg per day..
Usages associés
Antioxidant
NADH is both the primary coenzyme that triggers redox reactions during cellular metabolism. It's a powerful antioxidant.
Usages associés
Cardiovascular
NADH significantly reduces total cholesterol and LDL levels by up to 30% in rats and lowers blood pressure by 10% on average in humans after 12 weeks of daily 5 mg supplementation. This molecule also promotes cardiovascular health by strengthening heart muscles and dilating blood vessels, thanks to the increased production of nitric oxide (NO). This mechanism improves blood circulation and could benefit conditions like angina, asthma, and migraines.
Safety dosage
Adult from 18 years: 5 mg - 20 mg
NADH is most often used at doses of 5 to 10 mg per day for a period of up to 24 months. Doses up to 20 mg per day for eight weeks have also been used.
