Saw Palmetto: Benefits, Dosage, Contraindications
Other name(s)
Saw palmetto, Sabal
Scientific name(s)
Serenoa repens
Family or group:
Plants
Active ingredients:
Linoleic acid
Alpha-linolenic acid
Beta-sitosterol
Indications
Rating methodology
EFSA approval.
Hair Loss ✪✪✪✪✪
Preliminary clinical research shows that a combination of 200 mg of saw palmetto extract and 50 mg of beta-sitosterol taken twice daily improves subjective scores of hair quantity and quality in men with androgenetic alopecia. However, other clinical research indicates that taking 320 mg of saw palmetto extract per day for 24 months is less effective than taking 1 mg of finasteride per day in improving hair growth in men with androgenetic alopecia. Some early clinical research shows that saw palmetto lotion applied twice daily for 50 weeks improves hair density by 27% in men and women with androgenetic alopecia. However, it is not clear whether saw palmetto provided a statistically significant improvement compared to a placebo.
Posologie
Synergies
EFFECT OF GELATIN-CYSTINE AND SERENOA REPENS EXTRACT ON FREE RADICALS LEVEL AND HAIR GROWTH
A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-alpha-reductase in the Treatment of Androgenetic Alopecia
Benign Prostatic Hyperplasia ✪✪✪✪✪
There are numerous clinical studies on this topic, with smaller and shorter ones noting some slight to moderate improvements in urinary symptoms such as frequent urination, painful urination, urgency, and perineal heaviness. Some studies also show that saw palmetto reduces nocturia (the need to urinate at night), improves urinary flow, and reduces residual urine volume in patients with benign prostatic hyperplasia. However, larger and longer trials have noted no effect. The most recent Cochrane meta-analysis also reports no effect. Research results remain inconsistent. This may be due to different study methodologies, patient populations, symptom measurement methods, and saw palmetto products used in studies. Most clinical studies, including those yielding positive and negative results, have used liposterolic extracts of saw palmetto berries containing about 80% to 90% free fatty acids.
Posologie
Effect of increasing doses of saw palmetto extract on lower urinary tract symptoms: a randomized trial.
[Efficacy of Pretreatment With Serenoa Repens on Bleeding Associated With Transurethral Resection of Prostate]
Serenoa Repens (Permixon®) Reduces Intra- And Postoperative Complications of Surgical Treatments of Benign Prostatic Hyperplasia
Improving BPH symptoms and sexual dysfunctions with a saw palmetto preparation? Results from a pilot trial.
Serenoa repens monotherapy for benign prostatic hyperplasia (BPH): an updated Cochrane systematic review.
Serenoa repens extract for benign prostate hyperplasia: a randomized controlled trial.
Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia.
E/S/C/O/P: 2nd Edition of the ESCOP Monographs
Observational database serenoa repens (DOSSER): overview, analysis and results. A multicentric SIUrO (Italian Society of Oncological Urology) project.
Effects of Pumpkin Seed Oil and Saw Palmetto Oil in Korean Men With Symptomatic Benign Prostatic Hyperplasia
Randomized, double-blind, placebo-controlled trial of saw palmetto in men with lower urinary tract symptoms
Effects of Short-Term Dutasteride and Serenoa Repens on Perioperative Bleeding and Microvessel Density in Patients Undergoing Transurethral Resection of the Prostate
Prostatitis ✪✪✪✪✪
Saw palmetto may improve symptoms of prostatitis compared to no treatment in patients suffering from non-bacterial prostatitis. Other preliminary clinical evidence suggests that taking a daily saw palmetto extract for eight weeks, in addition to prulifloxacin 600 mg per day for 15 days, reduces pain and urinary symptoms more significantly than prulifloxacin alone in patients with bacterial prostatitis. However, other preliminary clinical research suggests that oral saw palmetto 325 mg taken for a year does not significantly improve non-bacterial prostatitis and chronic pelvic pain syndrome compared to treatment with finasteride 5 mg. Interestingly, preliminary clinical research shows that taking a complex based on saw palmetto, selenium, and lycopene for 8 weeks significantly improves symptoms and peak flow in patients suffering from chronic prostatitis and/or chronic pelvic pain syndrome compared to pre-treatment. However, these effects were less significant in patients treated with saw palmetto alone, indicating that saw palmetto might not be the sole active component of this combination.
Posologie
Synergies
[Efficiency and Safety of prostamol-Uno in Patients With Chronic Abacterial Prostatitis]
A Prospective, 1-year Trial Using Saw Palmetto Versus Finasteride in the Treatment of Category III Prostatitis/Chronic Pelvic Pain Syndrome
E/S/C/O/P: 2nd Edition of the ESCOP Monographs
European Union herbal monograph on Serenoa repens (W. Bartram) Small, fructus
Serenoa Repens Associated With Urtica Dioica (ProstaMEV) and Curcumin and Quercitin (FlogMEV) Extracts Are Able to Improve the Efficacy of Prulifloxacin in Bacterial Prostatitis Patients: Results From a Prospective Randomised Study
Serenoa Repens Extract Additionally to Quinolones in the Treatment of Chronic Bacterial Prostatitis. The Preliminary Results of a Long Term Observational Study
Properties
Anti-androgenic
Saw palmetto has anti-androgenic, antiproliferative, and anti-inflammatory properties that are believed to improve symptoms of benign prostatic hyperplasia (BPH). Monitoring of 5-alpha-reductase and dihydrotestosterone (DHT) is crucial as they play a significant role in certain health conditions. 5-alpha-reductase is an enzyme that converts testosterone into DHT, a more potent form of testosterone. High levels of DHT are associated with issues like benign prostatic hyperplasia (BPH) and androgenetic alopecia. Saw palmetto appears to non-competitively inhibit types 1 and 2 of 5-alpha-reductase and prevent the conversion of testosterone into DHT in vitro, which may help limit prostate growth. However, levels of 5-alpha-reductase in prostate tissue and serum testosterone, DHT, and PSA are not significantly reduced by saw palmetto in vivo. Inhibition of 5-alpha-reductase and prevention of testosterone conversion to DHT may also contribute to saw palmetto's activity in androgenetic alopecia. It's suggested that this condition involves increased follicular sensitivity to DHT, reducing their growth phase and size.
Usages associés
Anticancer
In laboratory studies, saw palmetto extract (Serenoa repens) has shown potential to fight cancer. It appears to inhibit an enzyme (urokinase-type plasminogen activator) linked to the spread of cancer cells in urological cancers. Furthermore, saw palmetto has demonstrated inhibitory effects on the growth and/or induction of cell death in several types of cancer cells, including various prostate, breast, kidney, bladder, colon, and lung cancers. These effects vary depending on the dose of the extract used.
Anti-inflammatory
Inflammatory mediators seem to contribute to the etiology of BPH. In men with benign prostatic hyperplasia (BPH), a saw palmetto extract appears to decrease tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta, which are markers of inflammation in prostate tissue. Laboratory results suggest saw palmetto inhibits lipoxygenase and cyclooxygenase (COX), which are involved in inflammation. Additionally, animal research suggests saw palmetto inhibits the accumulation of mast cells in the prostate.
Usages associés
Hormonal metabolism
Some animal research outcomes suggest that saw palmetto fruit extract has estrogenic activity due to its relatively high concentration of beta-sitosterol. However, human research outcomes suggest that the extract displays anti-estrogenic activity in prostate tissue of men with benign prostatic hyperplasia.
Safety dosage
Adult from 18 years: 160 mg - 320 mg
Long-term use is possible. If symptoms persist while using saw palmetto, a doctor or qualified health professional should be consulted. Symptoms: fever, spasms or blood in urine, painful urination, or urinary retention.
Interactions
Médicaments
Warfarin: weak interaction
A few cases of suspected interactions with warfarin have been reported. Increased INR values were described. If you are taking an anticoagulant medication such as warfarin (Coumadin), your prothrombin time test results will be expressed as an international normalized ratio (INR).
Oral contraceptives: moderate interaction
Saw palmetto might have anti-estrogenic effects. Its use may interfere with contraceptive medications.
Precautions
Child up to 18 years: avoid
Avoid due to lack of data.
Hepatic insufficiency: avoid
In cases of liver disorders, saw palmetto is not recommended.
Contraindications
Pregnant woman: prohibited
Saw palmetto has hormonal activity.
Breastfeeding woman: prohibited
Saw palmetto has hormonal activity.