Phosphatidylcholine: benefits, dosage, contraindications
Other name(s)
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Fatty Acids
Indications
Rating methodology
EFSA approval.
Ulcerative colitis ✪✪✪✪✪
Phosphatidylcholine has proven effective in improving symptoms and remission rates in patients with ulcerative colitis. Clinical research indicates that taking slow-release phosphatidylcholine-rich phospholipids (Sterpur P-30 Granulat) at doses of 1 to 4 g per day for 3 months can significantly increase chances of clinical remission. A pooled analysis of three randomized clinical trials showed that 49% of patients with chronic active ulcerative colitis achieved clinical remission with phosphatidylcholine, compared to those receiving a placebo.
Posologie
Oral
1 - 4 g
Cognitive decline ✪✪✪✪✪
Phosphatidylcholine may play a key role in preventing cognitive decline. A population study on 1259 men in Finland showed that those with the highest daily intake of phosphatidylcholine had a 28% reduced risk of developing dementia compared to those with the lowest intake, over an average follow-up period of 22 years. Additionally, preliminary clinical evidence indicates that a single 25 g dose of phosphatidylcholine can improve certain memory measures in healthy college students, highlighting phosphatidylcholine's potential in supporting cognitive functions and preventing age-related cognitive decline.
Posologie
Oral
25 g
Liver disorders ✪✪✪✪✪
Polyunsaturated phosphatidylcholine shows mixed results in treating liver disorders. Although a study did not show significant survival improvement in patients with acute alcoholic hepatitis after 24 months of treatment at 6 grams per day, it seems to reduce mortality in patients with subacute but not acute liver failure. In chronic hepatitis C, phosphatidylcholine combined with interferon helped reduce liver enzymes. Furthermore, taking 600 mg three times a day for 24 weeks improved liver ultrasound echogenicity and structure, indicating reduced steatosis, although liver function tests show great variability. Moreover, a 12-month treatment combining silymarin (milk thistle active), phosphatidylcholine, and vitamin E improved liver function tests and liver histology in patients with non-alcoholic fatty liver disease, highlighting phosphatidylcholine's potential in supporting liver health.
Posologie
Oral
1 g
Synergies
Polyunsaturated phosphatidyl-choline and interferon alpha for treatment of chronic hepatitis B and C: a multi-center, randomized, double-blind, placebo-controlled trial. Leich Study Group
Effectiveness of phosphatidylcholine in alleviating steatosis in patients with non-alcoholic fatty liver disease and cardiometabolic comorbidities (MANPOWER study)
Effectiveness of phosphatidylcholine as adjunctive therapy in improving liver function tests in patients with non-alcoholic fatty liver disease and metabolic comorbidities: real-life observational study from Russia
Properties
Neurological
Phosphatidylcholine is the main source of choline, a precursor of acetylcholine, a neurotransmitter involved in memory. While it is unclear if ingesting phosphatidylcholine increases acetylcholine levels, in animals with low acetylcholine levels, such as those with dementia, phosphatidylcholine supplements might increase acetylcholine levels.
Usages associés
Hepato-protective
Polyunsaturated phosphatidylcholine can protect against liver fibrosis and alcohol-induced oxidative stress, although the exact mechanisms remain unknown. In animal models and in vitro, it has shown protection against various types of experimental liver damage. Phosphatidylcholine is incorporated into hepatocyte plasma membranes, thereby improving membrane morphology, fluidity, and function.
Usages associés
Digestive effect
Phosphatidylcholine is present in colonic mucus and contributes to colon protection. Patients with reduced phosphatidylcholine levels in the mucosa have a decreased hydrophobic barrier, which may lead to inflammation and ulcerations. In animal studies, phosphatidylcholine has demonstrated a key role in gastrointestinal mucosal defense; it protects against experimentally induced colitis. Preliminary clinical research indicates that a slow-release phosphatidylcholine-rich product improves disease scores in adults with ulcerative colitis.
Usages associés
Safety dosage
Adult: 1 g - 6 g
Oral use of phosphatidylcholine is safe, even at high doses of up to 30 g per day for 6 weeks. Lower doses of up to 6 g daily have been well tolerated for up to 24 months.
Pregnant: 1 g - 5 g
Use of up to 5g during pregnancy poses no safety concerns.
