Phosphorus: Benefits, Dosage, Contraindications
Other name(s)
Aluminum Phosphate, Calcium Phosphate, Potassium Phosphate, Sodium Phosphate
Scientific name(s)
phosphorus
Family or group:
Minerals and Trace Elements
Indications
Rating methodology
EFSA approval.
Constipation ✪✪✪✪✪
Sodium phosphates are used as saline laxatives. Sodium phosphate is an FDA-approved ingredient among over-the-counter oral and rectal products to treat constipation. Additionally, sodium phosphate tablets are also approved by the FDA for colon cleansing before a colonoscopy. a05200 tablets were used, each containing 1.102 grams of monobasic sodium phosphate monohydrate and 0.398 grams of dibasic sodium phosphate anhydrous, taken with 8 ounces of water every 15 minutes for a total of 20 tablets the evening before the colonoscopy.
Posologie
Orally
4.5 g
Adults
sodium phosphate
Hypophosphatemia ✪✪✪✪✪
Oral sodium or potassium phosphate intake is effective in preventing and treating hypophosphatemia. The treatment of hypophosphatemia with oral phosphates requires monitoring of serum electrolyte levels to determine the appropriate dosage.
Posologie
Orally
550 mg
Adults
sodium phosphate
Digestive Disorders ✪✪✪✪✪
Aluminum phosphate and calcium phosphate are FDA-approved ingredients as over-the-counter antacids. a05200
Posologie
Orally
550 mg
Adults
aluminum phosphate
Bone Health ✪✪✪✪✪
European health authorities (EFSA, European Food Safety Authority and the European Commission) have determined that products containing phosphorus can claim to contribute to normal energy metabolism, normal cell membrane function, maintaining bone and teeth health, as well as children's growth and bone development.
Posologie
Orally
550 mg
Adults, Children
Acid-Base Balance ✪✪✪✪✪
Phosphate plays a major role in maintaining acid-base balance through renal excretion of hydrogen ions.
Posologie
Orally
550 mg
Children, Adults
Child Development ✪✪✪✪✪
European health authorities (EFSA, European Food Safety Authority and the European Commission) have determined that products containing phosphorus can claim to contribute to normal energy metabolism, normal cell membrane function, maintaining bone and teeth health, as well as children's growth and bone development.
Posologie
Orally
160 - 640 mg
Children
Kidney Stones ✪✪✪✪✪
Oral potassium phosphate intake can help prevent calcium oxalate kidney stones in patients with hypercalciuria. a05200 Potassium and sodium phosphate salts, providing 1200 to 1500 mg of elemental phosphate per day, have been used.
Posologie
Orally
1200 - 1500 mg
Adults
sodium phosphate
Sustained reduction in urinary calcium during long-term treatment with slow release neutral potassium phosphate in absorptive hypercalciuria
Sports Performance ✪✪✪✪✪
Some clinical research shows that phosphate salts can improve physical performance. Indeed, phosphate salts have been shown to increase levels of 2,3-diphosphoglycerate (2,3-DPG) in red blood cells, enhancing oxygen delivery to peripheral tissues. a05200 However, evidence regarding the effects of sodium phosphate on physical performance remains contradictory. a05200A very small clinical trial shows that taking 4 g of sodium phosphate in the form of tribasic dodecahydrate sodium phosphate for 6 days before a 16 km cycling trial increases average power by about 10% and decreases the time needed to complete the trial by 3% in trained male cyclists. a05200 Other small clinical trials show that taking the same form of sodium phosphate at 50 mg/kg of lean mass, in four divided doses per day, for 6 days, slightly improves work, power and maximal oxygen uptake during high-intensity cycling exercises. Other clinical research shows that oral calcium phosphate or potassium phosphate intake does not improve physical performance.
Posologie
Orally
4 g
6 - days
Adults
sodium phosphate
Effects of Sodium Phosphate Loading on Aerobic Power and Capacity in off Road Cyclists
Effect of repeated sodium phosphate loading on cycling time-trial performance and VO2peak
Sodium phosphate as an ergogenic aid
Osteoporosis ✪✪✪✪✪
In postmenopausal women with osteoporosis and low phosphate intake, taking 1800 mg of calcium per day as tricalcium phosphate for 12 months improves lumbar spine and hip density. a05200However, it is not more effective than taking the same amount of calcium as calcium carbonate.
Posologie
Orally
550 mg
Adults
tricalcium phosphate
Synergies
Properties
Essential
Phosphorus is an indispensable element for the body as it is involved in numerous cellular reactions, notably glycolysis and oxidative phosphorylation, which are the main sources of ATP. Phosphorus is also important for crucial metabolisms such as DNA, RNA synthesis, gluconeogenesis, and bone mineralization. Furthermore, phosphate plays a major role in maintaining acid-base balance through the renal excretion of hydrogen ions.
Usages associés
Bone Density
In adults, phosphorus accounts for 0.65% to 1.1% of the body. Phosphorus is primarily present in bone as hydroxyapatite (85%) and in the intracellular compartment (14%). At the bone level, phosphorus is necessary for osteogenesis and is likely transferred into osteoblasts via a Na/Pi cotransporter, probably type 3. Hypophosphatemia causes an increase in intestinal calcium absorption and an increase in blood calcium levels. This can inhibit the formation of new bone.
Usages associés
Digestive Effect
When taken orally, aluminum phosphate neutralizes gastric acid. On the other hand, sodium phosphates are used as saline laxatives. They cause a fluid influx into the intestine by osmotic action and increased peristalsis.
Usages associés
Safety dosage
Infant from 7 to 11 months: 160 mg
Child from 1 to 3 year(s): 250 mg
Child from 4 to 10 year(s): 440 mg
Child from 11 to 17 year(s): 640 mg
Adult from 18 year(s): 550 mg
Pregnant woman from 18 year(s): 550 mg
Breastfeeding woman from 18 years: 550 mg
Interactions
Médicaments
Erdafitinib: strong interaction
Taking erdafitinib with phosphate salts increases the risk of hyperphosphatemia. Patients taking erdafitinib are recommended to limit their phosphate intake to a maximum of 600 to 800 mg per day.
Plantes ou autres actifs
Phosphorus: moderate interaction
Calcium and phosphate interact in the intestine to form insoluble salts, reducing the absorption of calcium and phosphate. To avoid this interaction, calcium and phosphate doses should be spaced at least 2 hours apart.
Phosphorus: moderate interaction
Iron and phosphate interact in the intestine to form insoluble precipitates, reducing the absorption of iron and phosphate. This effect seems to be enhanced in the presence of calcium, which can stabilize the precipitate. Phosphates might also increase the oxidation of ferrous iron to the ferric form, which is less well absorbed. To avoid this interaction, iron and phosphate doses should be separated by at least 2 hours.
Phosphorus: moderate interaction
Magnesium binds phosphate in the intestine, reducing the absorption of magnesium and phosphate. Magnesium salts, generally in combination with aluminum or calcium salts, are used to reduce phosphate levels in patients with kidney failure. To avoid this interaction, magnesium and phosphate doses should be separated by at least 2 hours.
Precautions
Heart disorders: use with caution
Use sodium-containing phosphates with caution in persons with heart disease.
Cirrhosis: use with caution
Use sodium-containing phosphates with caution in persons with cirrhosis.
Kidney failure: use with caution
Serum electrolytes should be closely monitored in persons with mild to moderate kidney failure using phosphate.
