Umckaloabo: benefits, dosage, contraindications
Other name(s)
a:0:{}
Scientific name(s)
Pelargonium sidoides
Family or group:
Plants
Active ingredients:
Catechins
Gallic acid
Polyphenols
Indications
Rating methodology
EFSA approval.
Bronchitis ✪✪✪✪✪
Clinical studies and meta-analyses show that Pelargonium sidoides, administered within 48 hours of symptom onset, significantly reduces cough intensity and promotes faster symptom recovery after 7 days of treatment compared to placebo. The product used, EPs 7630, is administered in liquid form (30 drops three times a day) or in tablets (10-30 mg three times a day). In children, an adjusted dosage (10-20 drops three times a day) also reduces fever and medication needs.
Posologie
Treatment of acute bronchitis with EPs 7630: randomized, controlled trial in children and adolescents
Safety of Pelargonium extract EPs 7630 in young children with acute bronchitis
Effects of Pelargonium sidoides extract EPs 7630 on acute cough and quality of life - a meta-analysis of randomized, placebo-controlled trials
Faster recovery and reduced paracetamol use - a meta-analysis of EPs 7630 in children with acute respiratory tract infections
Cold, Respiratory infections ✪✪✪✪✪
Pelargonium sidoides extracts (EPs 7630) prove effective in reducing the severity and duration of common cold symptoms, notably cough and nasal congestion. A meta-analysis of five studies shows a decrease in subjective symptom intensity scores, reduction in the number of sick leave days, and improved sleep quality. Doses range from 1.5 mL to 3 mL three times a day for 5 to 10 days. Analyses also indicate comparable efficacy against human coronavirus infections (excluding COVID-19). These results position Pelargonium sidoides among the most promising plants against common respiratory infections.
Posologie
Effects of Pelargonium sidoides extract EPs 7630 on acute cough and quality of life - a meta-analysis of randomized, placebo-controlled trials
Herbal Medicines for Rhinosinusitis: A Systematic Review and Network Meta-analysis
Treatment of signs and symptoms of the common cold using EPs 7630 - results of a meta-analysis
Pelargonium Extract EPs 7630 in the Treatment of Human Corona Virus-Associated Acute Respiratory Tract Infections - A Secondary Subgroup-Analysis of an Open-Label, Uncontrolled Clinical Trial
Properties
Antimicrobial
The antimicrobial effect of Pelargonium sidoides is mainly attributed to its coumarins (particularly umckaline), tannins, and proanthocyanidins. These compounds inhibit the growth of many pathogenic bacteria by altering their cell membrane permeability, disrupting essential functions. Tannins, with their astringent properties, precipitate bacterial proteins, reducing their adherence to mucous membranes. Root extracts of Pelargonium sidoides, notably in acetone or standardized product form (EPs 7630), show antibacterial activity in vitro against various pathogens, including Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Streptococcus pneumoniae, and multi-resistant strains of Staphylococcus aureus. They also act against Hemophilus influenzae. Additionally, the root extract shows in vitro activity against Mycobacterium tuberculosis and other mycobacteria. However, antibacterial activity remains lower than that of conventional antibiotics like penicillin or erythromycin.
Usages associés
Immunomodulator
Pelargonium sidoides stimulates the innate and adaptive immune response. Root extracts enhance macrophage phagocytosis and activate dendritic cells, essential for antigen presentation. They also induce the release of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), promoting a rapid response against infections. This dual modulation and stimulation effect allows the plant to strengthen natural defenses without triggering an excessive reaction.
Usages associés
Antiviral
The antiviral properties of Pelargonium sidoides are attributed to its polyphenols, which directly inhibit viral replication. These compounds act by blocking the attachment of viruses to host cells, thus preventing their penetration and spread. Additionally, tannins strengthen the mucosal barrier, limiting virus invasion. These combined actions are particularly effective against viruses responsible for acute respiratory infections, such as rhinoviruses or influenza viruses.
Usages associés
Safety dosage
Adult: 30 mg - 1200 mg (standardized extract)
The tablet form is most often used at a dose of 10-40 mg three times a day for 7-10 days.
Child: 3 mL (fluid extract)
A specific extract of Pelargonium sidoides (EPs 7630, Dr. Willmar Schwabe Pharmaceuticals) at a dose of 3 ml per day was used in children aged 6 to 10 years for a period of up to 7 days.
Precautions
Pregnant woman: avoid
Insufficient data.
Lactating woman: avoid
Insufficient data.