Yerba mate: benefits, dosage, contraindications

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Yerba mate is a tree from the Aquifoliaceae family, native to the temperate and tropical regions of South America, notably between Brazil, Argentina, and Paraguay. It grows spontaneously along rivers and can reach up to 15 meters tall. Yerba mate is characterized by a robust trunk and smooth, ash-gray bark, evergreen yellow-green leaves, irregular and angular, and white to greenish flowers blooming between the Brazilian spring and summer, producing small reddish-violet fruits. Historically, yerba mate has been used for centuries by the indigenous peoples of South America, notably the Guarani, who prepared an infusion of the leaves for its stimulating and revitalizing effects. In the 16th century, this practice was adopted by Europeans, who called it "Jesuit tea" due to its introduction by Jesuit missionaries. The dried leaves of yerba mate are used to prepare an infusion rich in caffeine (about 70 mg per cup), theobromine, theophylline, and saponins, which are the main active components of this plant. This infusion is not only stimulating but also possesses diuretic and laxative properties. Traditional uses of yerba mate include treating fatigue, headaches, and nervous depression. Today, yerba mate is gaining interest for its potential beneficial effects on cardiovascular and metabolic diseases. Its active compounds may help boost metabolism and reduce appetite, making it a popular choice among dietary supplements for weight loss.
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Scientific name(s)

Ilex paraguayensis

Family or group: 

Plants

Active ingredients:

Caffeine

Theobromine

Theophylline


Indications

Rating methodology

EFSA approval.

Several clinical trials (> 2) randomized controlled with double blind, including a significant number of patients (>100) with consistently positive outcomes for the indication.
Several clinical trials (> 2) randomized controlled with double blind, and including a significant number of patients (>100) with positive outcomes for the indication.
One or more randomized studies or multiple cohorts or epidemiological studies with positive outcomes for the indication.
Clinical studies exist but are uncontrolled, with conclusions that may be positive or contradictory.
Lack of clinical studies to date that can demonstrate the indication.


Weight control
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Randomized controlled trials on obese Korean adults taking 3 g of yerba mate per day in divided doses for 6 to 12 weeks showed no reduction in weight, body mass index, or lipid levels compared to a placebo. However, a modest improvement in fat mass, waist-to-hip ratio, and waist circumference was observed. Other preliminary research on healthy women revealed that taking a 2 g dose of yerba mate reduced self-reported hunger and prospective consumption before exercise. Appetite limitation can aid in weight control.

Posologie

posologieOral: leaf

posologie3 g

formulationherbal tea


Metabolic syndrome
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Yerba mate might help manage metabolic syndrome. Scientific studies have shown that yerba mate can inhibit pancreatic lipase activity, which reduces fat absorption in the body. In humans, a study showed that regular consumption of yerba mate in the form of an infusion significantly reduced LDL cholesterol levels in normolipidemic and dyslipidemic subjects, and enhanced the effect of statin treatment in hypercholesterolemic patients. Additionally, yerba mate can aid in weight loss by increasing energy expenditure and reducing appetite.

Posologie

posologieOral: leaf

posologie2 - 6 g

formulationherbal tea


Sports performance
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Yerba mate is valued for its beneficial effects on athletes, thanks to its ability to alter metabolism during exercise and enhance performance. A clinical study showed that consuming 5 g of yerba mate per day for 5 days before a cycling exercise reduces completion time by 2% and modestly improves absolute power compared to a placebo in trained athletes. Before intense efforts, yerba mate increases fat oxidation by 23% above placebo, elevates lactate and glycerol levels, while decreasing free fatty acid levels. However, there is no change in total energy expenditure, maximum fat oxidation, or glucose levels.

Posologie

posologieOrally: leaf

posologie5 g

formulationherbal tea


Fatigue
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Yerba mate is traditionally used to combat asthenia and fatigue, thanks to its stimulant properties attributed to caffeine and other active compounds. Consuming yerba mate offers a natural solution to increase alertness and reduce feelings of tiredness.

Posologie

posologieOrally: leaf

posologie2 g

formulationherbal tea


Properties


Antihyperglycemic

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Yerba mate, rich in polyphenols, presents potential beneficial properties for diabetes management, particularly by inhibiting the harmful effects of chronic hyperglycemia. Laboratory research has shown that yerba mate extracts can inhibit the formation of advanced glycation end-products, these molecules that accelerate tissue aging by accumulating in cells. Yerba mate extract also reduces the activity of alpha-glucosidase and decreases the gene expression of intestinal SGLT1, contributing to a favorable modulation of carbohydrate metabolism.


Cardiovascular

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Yerba mate has shown interesting effects on blood circulation and cardiovascular health in several studies. It has been observed that yerba mate induces dose-dependent vasodilation, which may help improve blood flow. Moreover, yerba mate seems to have the potential to reduce blood viscosity in patients with hyperviscosity, a risk factor for various cardiovascular diseases. In fact, more viscous blood has a thicker consistency, which can make it harder to flow through small veins and arteries. Regular consumption of yerba mate tea over six weeks has shown a decrease in plasma and blood viscosity, improvement of nail capillary measures, reduction of red blood cell aggregation, and increased blood flow, offering potential protection against the formation of atherosclerotic plaques. Furthermore, yerba mate could inhibit platelet aggregation and modulate blood lipid levels. These effects are potentially mediated by changes in the production of prostaglandins and thromboxane.

Usages associés

Metabolic syndrome

Hypolipidemic

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Yerba mate has demonstrated hypolipidemic effects in hypercholesterolemic animals by reducing aortic cholesterol and the size of atherosclerotic lesions. In obese animals, yerba mate tea reduced serum and hepatic lipid levels. In overweight humans, a clinical study showed that standardized dry yerba mate extract had no effect on lipid parameters, except in those with an intermediate to high risk of cardiovascular disease, where it increased the (good) HDL cholesterol. Yerba mate's anti-inflammatory effects may contribute to its hypolipidemic actions, thanks to chlorogenic acid and saponins that reduce inflammation and improve glucose tolerance.


Metabolic

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Yerba mate is recognized for its beneficial effects on weight management due to its rich composition in caffeine, polyphenols, and saponins. These components act by increasing resting energy expenditure and promoting cellular thermogenesis, while reducing preadipocyte differentiation and lipid accumulation in adipocytes. In particular, caffeine stimulates lipolysis and fatty acid oxidation, although its effect on lipid oxidation is modest. Polyphenols like chlorogenic acid play a key role in reducing adipose tissue-induced inflammation, which can alleviate associated metabolic disorders. Additionally, yerba mate favorably alters the lipid profile by inhibiting pancreatic lipase activity, thereby decreasing fat absorption. Studies on animals and humans have shown that yerba mate consumption can significantly lower LDL cholesterol levels and increase HDL cholesterol levels, thus contributing to cardiovascular disease prevention. Furthermore, yerba mate improves insulin resistance and increases levels of glucagon-like peptides (GLP-1) and leptin, which can help improve satiety and reduce caloric intake. One study revealed that taking yerba mate before exercise could reduce hunger without affecting satiety. Thus, yerba mate might be an interesting adjunct for weight loss and metabolic syndrome.

Usages associés

Metabolic syndrome, Weight control

Neurological

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Yerba mate, rich in caffeine, possesses notable stimulating properties for the central nervous system and physical performance. In the brain, mate inhibits monoamine oxidase (MAO) activity by 40 to 50%, which helps limit the degradation of important neurotransmitters such as dopamine, adrenaline, noradrenaline, and serotonin. This inhibition contributes to increased neuronal activity and improved mood.

Usages associés

Fatigue

Diuretic

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Yerba mate contains caffeine, which has a diuretic effect. However, the body quickly adapts to this effect, reducing fluid loss associated with caffeine consumption.


Safety dosage

Adults from 18 years:

Dried leaves: 2 to 4 g in infusion for 10 to 15 min, 3 times a day.


Interactions

Médicaments

Carbamazepine: moderate interaction

Yerba mate contains caffeine which can reduce the anticonvulsant effect of carbamazepine and increase the risk of seizures.

Antidiabetic: weak interaction

Caffeine (in yerba mate) may have blood sugar-modulating properties and interfere with the effects of antidiabetic medications.

Adenosine: moderate interaction

Caffeine (in yerba mate) is a competitive inhibitor of adenosine and may reduce its vasodilator effect in humans.

CLOZAPINE: moderate interaction

Yerba mate contains caffeine, which may increase the effects and toxicity of clozapine, a drug used to treat certain psychiatric disorders. Caffeine may inhibit the metabolism of clozapine, potentially intensifying its effects and risks.


Contraindications

Pregnant women: prohibited

Yerba mate has been recognized as responsible for low birth weights and complications during childbirth.

Breastfeeding women: prohibited

Yerba mate is not recommended during breastfeeding.

Heart disorders: prohibited

Yerba mate is not indicated in the nervous state, tachycardia, and rhythm disorders.

Children up to 18 years: prohibited

Yerba mate is not recommended for children.