Amylase: Benefits, Dosage, Contraindications

Updated on 18 March 2025

Enzymes are among the most important products obtained for human needs from plant and microbial sources. Amylases are glycosidases that catalyze the hydrolysis of the glycosidic link in starch to generate smaller sugars. Amylase can be derived from several sources, such as plants, animals, and microorganisms. The amylase enzyme family has been well-characterized through the study of various microorganisms. Amylases are extracellular enzymes and are classified into three subtypes: - Alpha-amylase (α-amylase) - Beta-amylase (ß-amylase) - Gamma-amylase (γ-amylase) Amylase enzymes are also produced by the pancreas and the salivary glands. They help break down starch carbohydrates into sugars like glucose and maltose, making them easily absorbable by the body. Clinical applications include: - Acts on starch, glycogen, and related oligosaccharides. - In combination with other enzymes, as digestive aids. - As an anti-inflammatory. - In treating exocrine pancreatic deficiencies, amylaceous dyspepsia, and cystic fibrosis.

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Enzymes

Indications

Rating methodology

EFSA approval.

Several clinical trials (> 2) randomized controlled with double blind, including a significant number of patients (>100) with consistently positive outcomes for the indication.

Several clinical trials (> 2) randomized controlled with double blind, and including a significant number of patients (>100) with positive outcomes for the indication.

One or more randomized studies or multiple cohorts or epidemiological studies with positive outcomes for the indication.

Clinical studies exist but are uncontrolled, with conclusions that may be positive or contradictory.

Lack of clinical studies to date that can demonstrate the indication.

Digestion Issues
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Amylase plays an essential role in the digestion of complex carbohydrates. It mainly works by breaking down starch into maltose. Produced by the salivary and pancreatic glands, salivary amylase initiates digestion in the mouth, particularly of starches, carbohydrates, and sugars. The pancreatic version continues this process. Amylase facilitates the digestion of complex sugars by breaking down polysaccharides. Also present in some foods, it can be measured in the blood and urine. An increase in its level may indicate pancreatic or renal disorders and be related to abdominal pain.

Posologie

Orally

3000 - 15000 DU

Clinical applications of amylase: Novel perspectives

Type 2 Diabetes
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The use of amylase in the context of diabetes relies on its role in the digestion of complex carbohydrates. By helping to break down starch into simpler sugars, amylase can facilitate better management of blood glucose levels, a crucial aspect for diabetic individuals. Moreover, individuals with low amylase levels could be more prone to develop complications related to glucose metabolism. This imbalance can potentially lead to insulin resistance and type 2 diabetes. Integrating amylase supplements could, therefore, support the digestive process, particularly for those with insufficient secretion of this enzyme, thus improving glycemic regulation. This approach is part of a comprehensive diabetes control strategy, where a low glycemic index diet and medical monitoring remain crucial.

Posologie

Orally

3000 - 15000 DU

Clinical applications of amylase: Novel perspectives

Properties

Safety dosage

Adult: 3000 DU - 15000 DU

The dosages for adults in the context of supplementation range from 3000 DU to 15,000 DU or more. Reminder DU: Alpha-amylase Dextrinizing units. 1 DU = 48 USP (United States Pharmacopeia units). In the case of enzymes, the key measurement is the activity unit. There is no direct relationship between weight and activity units. Caution should be exercised with a product that only lists enzymes in mg.

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