Carcinine: benefits, dosage, contraindications

Mis à jour le 8 November 2025

Carcinine, a metabolite of L-carnosine, is a natural compound with powerful antioxidant and anti-glycation properties. It stands out for its ability to resist enzymatic degradation, thereby offering greater bioavailability. nnNumerous studies highlight its promising role in managing metabolic imbalances, particularly in patients with type 2 diabetes.nn

Family or group:

Amino acids

Indications

Scoring methodology

EFSA approval.

Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with consistently positive conclusions for the indication.

Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with positive conclusions for the indication.

One or more randomized studies, or several cohorts or epidemiological studies, with positive conclusions for the indication.

Clinical studies exist but are uncontrolled, with conclusions that may be positive or conflicting.

No clinical studies to date that can demonstrate the indication.

Wrinkles
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In a 4-month clinical study, 42 female participants were divided into two groups: an active group taking an oral formulation of carcinine and a placebo group. Participants in the active group took a 300 mg carcinine capsule every other day for 3 months. The results showed a significant improvement in skin quality, including reduced fine lines, firmer skin, and a brighter complexion. These benefits were observed through objective analysis of skin parameters using the Visioscan system, confirming carcinine's effectiveness in combating skin aging.

Posologie

Oral administration

300 mg

Skin beautification with oral non-hydrolyzed forms of carnosine and carcinine: effective therapeutic management and cosmetic skincare solutions against oxidative glycation and free-radical production as causal mechanisms of diabetic complications and skin aging

Type 2 diabetes
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A clinical study conducted on 100 overweight or obese patients with glycemic imbalances demonstrated the efficacy of carcinine in type 2 diabetes. The resu lts showed a significant decrease in blood glucose, glycated hemoglobin, and HOMA-IR index after 8 weeks of treatment. These positive effects were accompanied by a reduction in abdominal circumference and total cholesterol levels, without notable side effects.

Posologie

Oral administration

300 mg

The role of carcinine treatment in glyco-lipid imbalance in patients with altered blood glucose patterns

Properties

Hypoglycemic

Carcinine acts by reducing advanced glycation end-products (AGEs), molecules formed by the reaction between glucose and proteins or lipids. These AGEs are known to exacerbate diabetes-related vascular complications. According to a recent clinical study, taking 60 mg/day of carcinine over an 8-week period showed a significant decrease in AGEs measured by an AGE reader, contributing to a reduction in cardiovascular risks and diabetes complicationsnn

Usages associés

Type 2 diabetes

Anti-aging

Carcinine acts as a powerful inhibitor of advanced glycation, a key process in skin aging. It blocks the formation of advanced glycation end-products (AGEs), which cause stiffening of proteins such as collagen and a loss of skin elasticity. Through its ability to neutralize free radicals and interrupt oxidative chain reactions, carcinine protects dermal structures.nn

Usages associés

Wrinkles

Safe dosage

Adult: 300 mg

For anti-aging use or for preventing complications related to glycation, a dose of 300 mg/day has shown significant results.

Conseil scientifique