Chrysanthellum: Benefits, Dosage, Contraindications

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The Chrysanthellum is a herbaceous plant of the Asteraceae family originating from Peru and Bolivia. It is also common in Africa where it grows along paths, in wastelands and around homes, especially in high plateau regions. It develops at the end of the rainy season. The word Chrysanthellum comes from the Greek "chrusos" meaning gold and "anthemis" meaning chamomile. Indeed, the Chrysanthellum is also called "Golden Chamomile" and resembles chamomile overall. Chrysanthellum has yellow-orange flowers grouped in small heads. The parts used in phytotherapy are the aerial parts at the end of flowering. The active substances are flavonoids, saponins, and Chrysanthellines A and B. Traditionally, Chrysanthellum was indicated for gastrointestinal disorders. Chrysanthellum mainly has hepatoprotective properties. It is notably used in hepatobiliary disorders such as hepatitis or biliary stones. It is also venotonic and can benefit disorders related to venous insufficiency, including arteritis.

Other name(s) 

Golden Chamomile, American Chrysanthellum, Golden Chamomile

Scientific name(s)

Chrysanthellum indicum subsp. Afro americanum B. L. Turner

Family or group: 

Plants

Active ingredients:

Flavonoids

Saponins

Tannins

Alkaloids

Chlorogenic Acid

Caffeic Acid


Indications

Rating methodology

EFSA approval.

Several clinical trials (> 2) randomized controlled with double blind, including a significant number of patients (>100) with consistently positive outcomes for the indication.
Several clinical trials (> 2) randomized controlled with double blind, and including a significant number of patients (>100) with positive outcomes for the indication.
One or more randomized studies or multiple cohorts or epidemiological studies with positive outcomes for the indication.
Clinical studies exist but are uncontrolled, with conclusions that may be positive or contradictory.
Lack of clinical studies to date that can demonstrate the indication.


Venous Insufficiency
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The rich flavonoid and saponin content of Chrysanthellum confers a beneficial action on the circulatory system. It alleviates heavy legs through its venotonic action. Generally, 12 to 16 g of dry plant per day or its equivalent is used. In herbal tea (1 teaspoon = 2 g of plant), 3 to 4 teas per day preferably after meals. The tea is prepared by decoction and infusion in water.

Posologie

posologieOral Route: Aerial Parts

posologie1.2 - 2.4 g

populationAdults

formulationPowder, Tea/Infusion, Dry Extract


Detoxification
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Chrysanthellum is a plant known for its hepatoprotective virtues. Indeed, it can be used in cases of food or alcohol intoxication. French studies have demonstrated that Chrysanthellum also offers dramatic effects on alcohol elimination from the blood, with an increase of nearly 5 times the normal speed. It also has virtues for the regeneration of liver cells damaged by alcohol. Generally, 12 to 16 g of dry plant per day or its equivalent is used. In herbal tea (1 teaspoon = 2 g of plant), 3 to 4 teas per day preferably after meals. The tea is prepared by decoction and infusion in water.

Posologie

posologieOral Route: Aerial Parts

posologie1.2 - 2.4 g

populationAdults

formulationPowder, Tea/Infusion, Dry Extract


Hypercholesterolemia
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A study was conducted on 46 patients, who received a concentrated extract of Chrysanthellum in 10-day sequences each month for 3 months. When Chrysanthellum is used alone, an average cholesterol decrease of 17% and an average triglyceride decrease of 66% are noted. Generally, 12 to 16 g of dry plant per day or its equivalent is used. In herbal tea (1 teaspoon = 2 g of plant), 3 to 4 teas per day preferably after meals. The tea is prepared by decoction and infusion in water.

Posologie

posologieOral Route: Aerial Parts

posologie1.2 - 2.4 g

duration3 - months

populationAdults

formulationPowder, Tea/Infusion, Dry Extract


Peripheral Arterial Disease
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A clinical evaluation focused on 26 patients with arterial disease who received 300 mg per day of Chrysanthellum extract for 3 months, compared with 32 others who were only given a placebo. The treated patients reported an improvement in their symptoms and an increase in their spontaneous activity. There is an excellent correlation between the clinical improvement and the increase in blood flow as measured by Doppler effect, both in the lower limbs and in the supra-aortic arteries. In general, 12 to 16 g of dried plant per day or its equivalent is used. As a tea (1 teaspoon = 2 g of plant), 3 to 4 teas per day, preferably consumed after meals. The tea is prepared by decoction and infusion in water.

Posologie

posologieOral administration: aerial parts

posologie1.2 - 2.4 g

duration3 - months

populationAdults

formulationpowder, tea/infusion, dry extract


Hepatic disorders
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The main activity of chrysanthellum is liver detoxification and hepatocyte regeneration. This effect is due to the presence of flavonoids and saponins. The mechanism of liver tissue regeneration is through induction of microsomal enzyme reactions, particularly by inducing cytochrome P450. Chrysanthellum also promotes bile drainage and facilitates the elimination of triglycerides and cholesterol.

Posologie

posologieOral administration: aerial parts

posologie1.2 - 2.4 g

formulationpowder, tea/infusion, dry extract


Kidney stones
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Reducing uric acid levels can help limit the risk of kidney stone formation, especially those composed of uric acid. In a clinical study, in patients with asymptomatic hyperuricemia, taking a specific combination of Chrysanthellum flower extract and cinnamon bark extract at a dose of 4 grams twice a day for 12 weeks reduced serum uric acid compared to patients on placebo.

Posologie

posologieOral administration: aerial parts

posologie8 g

duration12 - weeks

formulationpowder, tea/infusion, dry extract


Synergies


Properties


Hepatoprotective

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The main activity of chrysanthellum is liver detoxification and regeneration of hepatocytes. This effect is due to the presence of flavonoids and saponins. The mechanism of hepatic tissue regeneration occurs through the induction of microsomal enzymatic reactions, particularly by inducing cytochrome P450. Chrysanthellum also promotes bile drainage and facilitates the elimination of triglycerides and cholesterol.

Usages associés

Detoxification, Biliary Disorders, Hepatic Disorders

Microcirculatory Effect

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Chrysanthellum is proposed for preventive or curative treatment of vascular disorders. Indeed, it has positive effects on capillary permeability and fragility, as well as peripheral microcirculation, thanks to its vitamin P properties. Other data suggest that chrysanthellum could increase coronary vasodilation and blood flow without increasing coronary contractility or oxygen consumption. It may also reduce histamine-induced capillary permeability.

Usages associés

Venous Insufficiency, Peripheral Arterial Disease

Antioxidant

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It has been shown in vitro that flavonoids decrease lipid peroxidation. Indeed, flavonoids are free radical scavengers.


Anti-inflammatory

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Flavonoids have anti-inflammatory properties by inhibiting 5-lipoxygenase and thus the production of leukotrienes, mediators of inflammation and allergic manifestations.


Hypolipidemic

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Chrysanthellum has hypolipidemic properties. A study examined the action of Chrysanthellum on cholesterol and triglycerides, first in patients receiving only Chrysanthellum alone, and in others where chrysanthellum was combined with various medications, usually of plant origin. When Chrysanthellum is used alone, an average cholesterol decrease of 17% and an average triglyceride decrease of 66% occur. When Chrysanthellum is used in combination, an average decrease of 16% is observed for cholesterol and 72% for triglycerides. Moreover, triglycerides are more strongly influenced by Chrysanthellum than cholesterol.

Usages associés

Hypercholesterolemia

Uricosuric Effect

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The extract of chrysanthellum has an antilithiasic effect both biliary and urinary. A combination of Chrysanthellum flower extract and cassia cinnamon bark extract reduces serum uric acid levels in rats and promotes the excretion of uric acid in urine.

Usages associés

Kidney Stones


Safety dosage

Adult from 18 years: 1.2 g - 2.4 g (powder, tea/infusion)

In dry extract (400 mg capsules): 1,200 to 2,400 mg of dry extract per day in four or six doses at the end or middle of meals.


Precautions

Allergies: avoid

Chrysanthellum contains sesquiterpene lactones. Therefore, it is not recommended for people allergic to plants of the Asteraceae family.


Contraindications

Pregnant women: prohibited

Chrysanthellum is contraindicated for pregnant women.

Breastfeeding women: prohibited

Chrysanthellum is contraindicated for breastfeeding women.

Children up to 18 years: prohibited

Chrysanthellum is contraindicated for children.