Glucomannan: Benefits, Dosage, Contraindications
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Phytosubstances
Indications
Rating methodology
EFSA approval.
Constipation ✪✪✪✪✪
Glucomannan is generally effective for treating constipation in adults. Clinical research shows that an oral intake of 1 to 1.5 g of glucomannan three times a day for 3 to 5 weeks may relieve constipation. It acts as a bulk-forming laxative by increasing stool volume. In pregnant women, the combination of glucomannan and lactulose also seems effective in alleviating constipation.
Posologie
Oral
1 - 1.5 g
Fiber (glucomannan) is beneficial in the treatment of childhood constipation
Glucomannan is not effective for the treatment of functional constipation in children: a double-blind, placebo-controlled, randomized trial
Type 2 Diabetes ✪✪✪✪✪
Limited research suggests that glucomannan may improve glycemic control and lipid profiles in type 2 diabetic patients. The usual dose ranges from 3 to 15 g per day over 4 to 12 weeks, showing modest improvement in fasting glucose, total cholesterol, and LDL, but without significant impact on triglycerides.
Posologie
Oral
3 - 15 g
Effects of Glucomannan Supplementation on Type II Diabetes Mellitus in Humans: A Meta-Analysis
Nutraceutical resources for diabetes prevention--an update
Dyslipidemia ✪✪✪✪✪
The majority of clinical research indicates that glucomannan can lower cholesterol levels in both healthy individuals as well as those with hyperlipidemia. Meta-analyses show that taking 2.5 to 15 g of glucomannan per day for up to 12 weeks can significantly reduce total cholesterol, LDL, and triglycerides. Glucomannan is often taken at doses of 5 to 10 g per day in adults and 2 to 3 grams per day in children.
Posologie
Oral
5 - 10 g
Effects of Glucomannan Supplementation on Type II Diabetes Mellitus in Humans: A Meta-Analysis
A systematic review and meta-analysis of randomized controlled trials of the effect of konjac glucomannan, a viscous soluble fiber, on LDL cholesterol and the new lipid targets non-HDL cholesterol and apolipoprotein B
Obesity ✪✪✪✪✪
Although some low-quality research indicates that oral glucomannan may be beneficial for slight improvements in body weight, other studies do not support this claim. Meta-analyses on the use of glucomannan to improve weight and body composition in overweight or obese adults and children show mixed results. One analysis suggests that glucomannan reduces body weight by about 0.8 kg compared to placebo, while another finds no improvement. Reasons for these divergent results may be related to differences in study populations, dosages, and length of treatment, as well as often poor methodological quality of studies conducted so far.
Posologie
Oral
2 - 4 g
Effects of Konjaku Flour on the Gut Microbiota of Obese Patients
Gummies candy enriched with Konjac glucomannan reduces hunger intensity and waist circumference of overweight individuals
Properties
Cardiovascular
Glucomannan may improve glycemic control by slowing gastric emptying and increasing the viscosity of gastrointestinal contents, positively impacting blood glucose levels. Furthermore, glucomannan promotes the fecal excretion of cholesterol and bile acids and inhibits hepatic cholesterol synthesis. Clinical evidence also suggests that glucomannan can reduce triglycerides by increasing levels of lipoprotein lipase (LPL) and GPIHBP1 protein, which work jointly to hydrolyze triglycerides and deliver lipid nutrients to target tissues.
Usages associés
Laxative
Glucomannan, a water-soluble carbohydrate, acts as a laxative by increasing water absorption by the stool and reducing intestinal transit time. Clinical studies have shown its effectiveness in treating constipation.
Safety dosage
Adult: 3 g - 10 g
Glucomannan is commonly used in doses of 3 to 10 grams per day, in a single intake or divided doses, for up to 3 months. Caution: It's important to drink plenty of water. Cases of choking and esophageal or gastrointestinal obstruction have been reported when glucomannan products are taken dry.
Child: 2 g - 5 g
In children, glucomannan has been used in doses of 2 to 5 g per day, in a single intake or divided doses, for up to 4 months. Caution: It's important to drink plenty of water. Cases of choking and esophageal or gastrointestinal obstruction have been reported when glucomannan products are taken dry.
Interactions
Médicaments
Oral medications: moderate interaction
Glucomannan can reduce the absorption of certain medications due to the viscosity and swelling effect of glucomannan. To avoid changes in absorption, it is recommended to take glucomannan 30 to 60 minutes after taking oral medications.
