Lactase (digestive enzyme): benefits, dosage, contraindications

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Lactase is an enzyme in the intestine that breaks down lactose into glucose and galactose. Some people are "lactose intolerant" and are unable to break down lactose on their own. This can cause cramps, diarrhea, and gas, prompting them to avoid milk and dairy products. Lactase is actively produced during childhood when milk is the primary source of nutrition. The enzyme then becomes less active after the weaning phase, significantly decreasing in adulthood. However, production is uneven; 70% to 80% of Caucasian individuals produce this enzyme in adulthood, but it's the case for only about 10% of Asian individuals. Commercially available lactase is derived from Candida pseudotropicalis or Kluyveromyces lactis. Taken orally, lactase is used for lactose intolerance and colic.
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Enzymes


Indications

Rating methodology

EFSA approval.

Several clinical trials (> 2) randomized controlled with double blind, including a significant number of patients (>100) with consistently positive outcomes for the indication.
Several clinical trials (> 2) randomized controlled with double blind, and including a significant number of patients (>100) with positive outcomes for the indication.
One or more randomized studies or multiple cohorts or epidemiological studies with positive outcomes for the indication.
Clinical studies exist but are uncontrolled, with conclusions that may be positive or contradictory.
Lack of clinical studies to date that can demonstrate the indication.


Properties


Safety dosage

Adult: 2000 IU - 9000 IU

Lactase is generally recognized as safe when prepared from Candida pseudotropicalis or Kluyveromyces lactis. Lactase has been used safely at doses up to 9900 international units (IU).

Child:

Adjust the dose according to manufacturer instructions and the child's age.

Pregnant woman: 2000 IU - 9000 IU

Probably safe for pregnant women. Consume with foods containing lactose.

Breastfeeding woman: 2000 IU - 9000 IU

Probably safe for breastfeeding women. Consume with foods containing lactose.