Lipase (digestive enzyme): Benefits, Dosage, Contraindications
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Lipase is a digestive enzyme that breaks down triglycerides. It encompasses a group of enzymes found in animals and plants. Acid-resistant lipase is used as a dietary supplement. This sheet refers to supplements that contain only lipase from non-pancreatic sources. Pancreatic sources of lipase also contain other digestive enzymes.
Lipase is a digestive enzyme widely present in the plant world and is also found in milk, dairy products, bacteria, molds, and animal tissues. Castor seeds and hulled oats are also plant-based sources of lipases that are stable in acidic environments. Lipase facilitates the digestion of fats by hydrolyzing triglycerides in the stomach and small intestine. Lipase supplements are destroyed by gastric acid.
Orally, lipase is used for dyspepsia, heartburn, celiac disease, inflammatory bowel diseases (IBD), and cystic fibrosis. It is also used in pasteurized breast milk or infant formula for premature infants.
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Enzymes
Indications
Rating methodology
EFSA approval.
Several clinical trials (> 2) randomized controlled with double blind, including a significant number of patients (>100) with consistently positive outcomes for the indication.
Several clinical trials (> 2) randomized controlled with double blind, and including a significant number of patients (>100) with positive outcomes for the indication.
One or more randomized studies or multiple cohorts or epidemiological studies with positive outcomes for the indication.
Clinical studies exist but are uncontrolled, with conclusions that may be positive or contradictory.
Lack of clinical studies to date that can demonstrate the indication.
Digestive Disorders ✪✪✪✪✪
A small clinical trial shows that taking a specific acid-resistant lipase of 280 mg immediately before a high-fat meal reduces postprandial bloating and nausea compared to placebo in people suffering from postprandial distress syndrome.
Posologie
Orally
280 mg
