Melilot: Benefits, Dosage, Contraindications

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Melilot is a biennial plant belonging to the Fabaceae family, commonly found in Europe. It grows in calcareous or slightly salty soils and adapts to altitudes up to 2200 meters. Its stems can reach one meter in height, bearing trifoliate leaves and fragrant yellow flowers grouped in clusters, blossoming from May to September and highly appreciated by bees, hence the name "meli" meaning "honey". Historically, melilot was already mentioned by ancient medicine figures like Hippocrates and Dioscorides for its effects on stomach and liver pains. In the Middle Ages, its sedative properties were recognized. The flowering tops of the plant are the parts used in phytotherapy. Melilot is rich in coumarins, especially melilotin which gives it mild anticoagulant properties. It also contains flavonoids such as kaempferol and phenolic acids such as salicylic acid. These components contribute to its veno-lymphatic effects, reducing inflammation and improving microcirculation. Modern uses of melilot extend to the treatment of venous insufficiency, lymphedemas, and hemorrhoids. Its extracts are standardized to contain at least 0.3% coumarin, ensuring efficacy and safety in its therapeutic applications.

Other name(s) 

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Scientific name(s)

Melilotus officinalis

Family or group: 

Plants

Active ingredients:

Coumarins

Phenolic Acids


Indications

Rating methodology

EFSA approval.

Several clinical trials (> 2) randomized controlled with double blind, including a significant number of patients (>100) with consistently positive outcomes for the indication.
Several clinical trials (> 2) randomized controlled with double blind, and including a significant number of patients (>100) with positive outcomes for the indication.
One or more randomized studies or multiple cohorts or epidemiological studies with positive outcomes for the indication.
Clinical studies exist but are uncontrolled, with conclusions that may be positive or contradictory.
Lack of clinical studies to date that can demonstrate the indication.


Bruise, Hematomas
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Melilot is traditionally used to treat bruises and hematomas due to its beneficial effects on circulation and its anti-inflammatory effect. Active compounds like coumarin in melilot reduce capillary permeability and improve microcirculation, which can help reduce swelling and accelerate the resolution of bruises. The EMA also approves melilot for the treatment of minor skin inflammations, confirming its traditional use in these contexts.

Posologie

posologieTopical: Flowering tops

posologie3 - 6 g

formulationpatch, liquid extract


Hemorrhoids
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Melilot, due to its anti-inflammatory and vasoprotective properties, is traditionally used to relieve hemorrhoid symptoms.

Posologie

posologieOral: Flowering tops

posologie480 - 750 mg

formulationhydro-alcoholic extract, dry extract


Venous Insufficiency, Varicose Veins, Spider Veins, Edema
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Melilot provides benefits due to its effects on the veno-lymphatic system. By improving vascular tone and increasing lymphatic flow, melilot helps reduce venous stasis, a key factor in the development of varicose veins and hemorrhoids. Additionally, melilot's activation of phagocytes helps decrease local inflammation, offering relief in cases of varicose veins and hemorrhoids where inflammation and pain are often present. Melilot's ability to promote healing and tissue regeneration can also be beneficial in the repair of vascular damage associated with phlebitis. The European Medicines Agency (EMA) recognizes melilot as a traditional product for relieving symptoms of discomfort and heaviness of the legs related to minor venous circulatory disorders.

Posologie

posologieOral: Flowering tops

posologie480 - 750 mg

formulationhydro-alcoholic extract, dry extract


Heavy Legs
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Melilot is traditionally used to relieve symptoms of heaviness in the legs linked to mild venous circulatory disorders, in accordance with the EMA's indication.

Posologie

posologieTopical: Flowering tops

posologie3 - 6 g

formulationpatch, liquid extract


Properties


Vascular Effect

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Melilot exerts notable effects on the vascular system, particularly due to its myotropic properties that actively stimulate the lymph and venous system. Coumarins, active compounds of melilot, improve vessel tone by increasing the rate and strength of lymphatic contractions, while reducing capillary permeability. This action promotes better tissue oxygenation through a significant improvement in microcirculation. These combined effects contribute to better management of lymphedemas and a general increase in lymphatic vascular activity.

Usages associés

Bruise

Microcirculatory Effect

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Melilot contains substances known as benzopyrones, particularly alpha-benzopyrones like coumarins. These compounds enhance blood circulation in small vessels by stimulating lymphatic vessel contraction and activating macrophages for a protein degradation effect. This can help reduce swelling and inflammation in affected tissues.

Usages associés

Venous insufficiency, Hemorrhoids, Heavy legs

Antiplatelet/Anticoagulant

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Coumarins have anticoagulant activity.a0


Safety dosage

Adult from 18 years:

- For internal use, the recommended dose is 1 to 5 mg of coumarin per day, delivered as a melilot preparation. - As an infusion, the recommended dose is 1 to 1.2 g per infusion, 1 to 2 times a day. - As a dry extract, the recommended dose is 250 mg, 3 times a day.


Interactions

Médicaments

Antiplatelet/Anticoagulant: moderate interaction

Melilot contains coumarinic acids, which have anticoagulant activity.


Contraindications

Liver disorders: prohibited

Melilot is contraindicated for individuals suffering from liver problems.

Children up to 18 years: prohibited

Melilot is contraindicated for pregnant and breastfeeding women, as well as for children under 18 years old.

Pregnant woman: prohibited

Melilot is contraindicated for pregnant and breastfeeding women, as well as for children under 18 years old.

Breastfeeding woman: prohibited

Melilot is contraindicated for pregnant and breastfeeding women, as well as for children under 18 years old.