Phytase: Benefits, Dosage, Contraindications
Other name(s)
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Enzymes
Indications
Rating methodology
EFSA approval.
Wrinkles ✪✪✪✪✪
In patients with deep wrinkles, preliminary clinical research shows that taking 50 mg of zinc citrate and 3,000 units of phytase per day for four days before botulinum toxin treatment increases the duration of botulinum toxin effects reported by the patient by about 25%, while there is no improvement in patients taking 10 mg of zinc gluconate or a placebo. The effectiveness of botulinum toxin treatment was also improved.
Posologie
Oral use
3000 IU
Synergies
Anemia ✪✪✪✪✪
Taking phytase with a meal containing phytate and iron increases iron absorption. However, the effect of phytase specifically for the treatment of iron-deficiency anemia remains unclear. In a small study involving women, some suffering from iron-deficiency anemia, incubating wheat as a source of phytase with a traditional cereal rich in phytate increased iron absorption from the meal from 2.6% to 8.3%. Similarly, adding microbial phytase to whole wheat rolls containing phytate increases iron absorption from a meal by about 82% compared to rolls without added phytase. In another small study, adding microbial phytase to a simple maize meal with added micronutrients increased iron absorption and its incorporation into red blood cells by 1.85 times after 14 days, compared to the meal without added phytase.
Posologie
Oral use
1000 IU
Dietary Aspergillus niger phytase increases iron absorption in humans
Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial
The effect of lipids, a lipid-rich ready-to-use therapeutic food, or a phytase on iron absorption from maize-based meals fortified with micronutrient powders
Zinc Deficiency ✪✪✪✪✪
Preliminary clinical research shows that adding phytase at a rate of 20.5 units to a zinc-fortified millet-based dish increases zinc absorption by about 68% in children aged 12 to 24 months. Some of these children had low plasma zinc levels at the start. However, the use of phytase specifically for the treatment of zinc deficiency has not been studied.
Posologie
Oral use
20.5 IU
Properties
Remineralizing
Dietary phytate or phytic acid binds to minerals and reduces their bioavailability. Phytase breaks down dietary phytate by catalyzing the gradual removal of phosphates from phytate, which increases the release of chelated minerals. Microbial phytases are active at a pH of 2.0 and withstand heat and gastric acids. Endogenous phytases present in foods are generally active at a pH of 4.5-6.0 and in a temperature range of 45-60°C. Soaking sources of phytase foods in the appropriate temperature range has a significant effect on the bioavailability of minerals. Fermentation with phytase-producing microorganisms also increases the bioavailability of minerals.
Safety dosage
Adult from 18 years: 3000 IU - 10000 IU
Phytase activity is measured in phytase units, or FTU, with one unit representing the amount of enzyme that releases 1 mmol of inorganic phosphorus per minute.
Precautions
Pregnant woman: avoid
Insufficient data.
Breastfeeding woman: avoid
Insufficient data.
