Rosmarinic Acid: Benefits, Dosage, Contraindications
Other name(s)
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Family or group:
Phytochemicals
Indications
Rating methodology
EFSA approval.
Allergies ✪✪✪✪✪
A clinical study evaluated the efficacy of rosmarinic acid in treating seasonal allergic rhinoconjunctivitis. In a double-blind randomized trial, 29 participants received 200 mg, 50 mg of rosmarinic acid, or a placebo per day for 21 days. The results revealed a significant reduction in symptoms such as nasal itching and watery eyes in the 200 mg group, accompanied by a decrease in eosinophil and neutrophil counts in nasal lavage fluid compared to the placebo. No notable adverse effects were reported.
Posologie
Orally
200 mg
standardized extract
Dermatoses ✪✪✪✪✪
In a study on atopic dermatitis, 21 participants with mild forms of the condition applied a cream containing 0.3% rosmarinic acid to affected areas twice daily for 8 weeks. The results showed a significant decrease in erythema and trans-epidermal water loss compared to a placebo. Additionally, the SCORAD index, measuring the severity of atopic dermatitis, significantly improved. Participants also reported a reduction in symptoms such as dryness and itching, demonstrating rosmarinic acid's potential as a safe and effective topical treatment for inflammatory skin conditions.
Posologie
Orally
0.3 %
cream
Cognitive decline ✪✪✪✪✪
A randomized controlled trial explored the effects of a standardized Melissa officinalis extract containing rosmarinic acid in older adults with mild cognitive decline. Participants received 300 mg of this extract daily for 16 weeks. Results showed improvement in cognitive functions, notably verbal and working memory, in the treated group compared to the placebo. These benefits are likely related to rosmarinic acid's antioxidant and anti-inflammatory properties, suggesting its potential role in preventing age-related cognitive decline.
Posologie
Orally
42 mg
standardized extract
Properties
Anti-inflammatory
Rosmarinic acid acts by inhibiting pro-inflammatory mediators such as cytokines (IL-12, IL-6) and enzymes (COX-2, iNOS). These mechanisms are enhanced by its regulatory effect on NF- 3Ba and STAT3, two key pathways in chronic inflammation. Studies show efficacy in models of arthritis and colitis.
Usages associés
Neurological
Thanks to its antioxidant and anti-apoptotic properties, rosmarinic acid protects nerve cells against oxidative stress and inflammation. It modulates pathways like ERK1/2 and reduces the accumulation of toxic proteins (such as A 32 in Alzheimer's disease). This action also promotes neurogenesis in the hippocampus, suggesting potential for neurodegenerative disorders.
Usages associés
Anti-allergic
Rosmarinic acid reduces respiratory allergy symptoms by inhibiting histamine release from mast cells and regulating Th2 responses. Its effect on allergic rhinitis has been demonstrated by a significant reduction of inflammatory cytokines and eosinophils in clinical studies.
Usages associés
Safety dosage
Adult: 40 mg - 200 mg
For an adult, rosmarinic acid is primarily used in the form of plant extracts like lemon balm (Melissa officinalis) or rosemary (Rosmarinus officinalis), which are rich in it. Dosages vary according to the indication: - For mild cognitive disorders, a standardized extract of lemon balm containing about 14% rosmarinic acid is generally administered at a rate of 300 mg per day, equivalent to a dose of about 42 mg of rosmarinic acid. - For allergies or inflammation, extracts rich in rosmarinic acid can be dosed at 200-300 mg of pure rosmarinic acid per day, according to available studies.
