Silicon: benefits, dosage, contraindications

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Silicon is a nonmetallic element with an atomic weight of 28. Silicon derivatives are poorly soluble. Their solubility is related to the abundance of Si - OH groups and their accessibility on the outside of the molecule. Silicon is very abundant in nature; it is the second element after oxygen, representing 28% of the Earth's crust. It is found abundantly in the mineral world, where it plays an essential structural role (like carbon in organic matter). It is also found in plants and animals where it occupies a secondary place, most often related to structure or protection. In humans, the incorporation of silicon by the body begins as early as the fetal stage in the brain, muscles and spleen, before diversifying to other organs. The adult body contains approximately 7 grams of silicon in total, which places it, like iron (4 grams), in an intermediate position between minerals (sodium, potassium, calcium, magnesium, phosphorus) and trace elements. Silicon exists in mineral form (silicic acid) and in organic form, incorporated into macromolecules. In the blood, about 5 mg/L is found, mostly in free form, not bound to proteins. Its distribution is uneven in tissues. It is abundant in: - The connective tissue that provides connection, support and flexibility, - The cartilaginous tissue, - The skin and appendages, - The lymphoid tissue, - The lung and the adrenal glands. It is mainly found in areas of growth and regeneration. Silicon is present in tap water, some spring waters and mineral waters, in cereals, seeds and beer. The presence of silicon is necessary for the biosynthesis of certain molecules such as collagen, elastin and hyaluronic acid and therefore influences all tissues where these substances play an important role: connective tissue in general, and more particularly cartilage, bones, skin and the immune system.

Other name(s) 

Orthosilicic acid, silica

Scientific name(s)

Silicon, Si

Family or group: 

Minerals and trace elements


Indications

Scoring methodology

EFSA approval.

Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with consistently positive conclusions for the indication.
Several randomized, double-blind, controlled clinical trials (> 2), including a significant number of patients (>100), with positive conclusions for the indication.
One or more randomized studies, or several cohorts or epidemiological studies, with positive conclusions for the indication.
Clinical studies exist but are uncontrolled, with conclusions that may be positive or conflicting.
No clinical studies to date that can demonstrate the indication.


Osteoporosis
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Men and premenopausal women who have a higher dietary intake of silicon appear to have higher bone mineral density, which could reduce the risk of osteoporosis. Another clinical study suggests that a higher silicon intake increases bone mineral density in postmenopausal women on hormone replacement therapy (HRT). This effect was not observed in women who are not on HRT. Bone loss in postmenopausal women is mainly due to bone resorption. Silicon appears to affect only bone formation.

Posologie

posologieOral administration

posologie40 mg


Wrinkles
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A small preliminary clinical study conducted on healthy volunteers aged 40 to 60 years shows that taking a specific product containing 600 mg of organic silicon in hydrolyzed marine collagen once daily for 90 days improves the firmness, hydration, and texture of the skin, but not wrinkles, radiance, or softness, compared with placebo.

Posologie

posologieOral administration

posologie600 mg


Synergies


Joint pain
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Silicon is suggested to relieve rheumatism (osteoarthritis). In a multicenter, randomized, double-blind study, choline-stabilized orthosilicic acid showed symptomatic improvement in men, but not in women, after 12 weeks of supplementation, which was associated with a small but significant reduction in biomarkers related to cartilage degradation.

Posologie

posologieOral administration

posologie5 mg


Hair beauty
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Silicon helps maintain the health of hair, nails and/or skin. Moreover, arterial walls contain large quantities of collagen and elastin synthesized by fibroblasts. Silicon is involved in the synthesis and arrangement of elastin, collagen and mucopolysaccharide fibers and is therefore essential.

Posologie

posologieOrally

posologie10 mg


Skin health
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Silicon helps maintain the health of hair, nails and/or skin. Silicon is concentrated in the skin and even more so in the nails, body hair and scalp hair. It contributes to the strength and high resistance of keratinized tissues.

Posologie

posologieOrally

posologie10 mg


Synergies


Properties


Bone density

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In animal research, a silicon deficiency caused major structural abnormalities of the skull and long bones, strongly suggesting that silicon is necessary for normal bone development. Human research has shown that increased dietary silicon intake is associated with increased bone mineral density in men and premenopausal women. Other human studies have demonstrated an association between silicon intake and trabecular bone volume and bone mineral density (BMD) in osteoporotic subjects, and between markers of bone formation and BMD in women with low bone mass. Orthosilicic acid appears to stimulate osteoblasts in humans. In vitro research suggests that the mechanism of action of silicon includes stimulation of collagen synthesis and other molecules associated with production of the extracellular matrix.

Usages associés

Osteoporosis, Joint pain

Dermatological effect

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Silicon enables the formation of collagen, elastin and structural glycoproteins. It induces or regulates fibroblast proliferation and promotes the formation of fibrous proteins (mainly represented by collagen and elastin). These fibers are responsible for the suppleness and elasticity of connective tissue. Silicon concentrates in the skin and even more so in nails, body hair and hair. It contributes to the strength and high resistance of keratinized tissues. Low levels have been observed when keratinization is incomplete (psoriasis, exfoliative dermatitis) and high levels in cases of hyperkeratinization. Furthermore, skin aging is correlated with a decrease in silicon. Silicon also prevents hair loss and, in some cases, promotes regrowth.

Usages associés

Wrinkles, Hair beauty, Skin health

Anti-aging

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Several factors contribute to the aging process, including degeneration of the functional matrix (connective tissue). The extracellular matrix, composed of collagen and elastin fibers as well as glycosaminoglycans, provides these tissues with mechanical properties and also helps regulate metabolic activity. Silicon is involved in the metabolism of collagen, elastin and glycosaminoglycans; therefore its deficiency promotes aging of the skin, joints (with osteoarthritic changes) and bones (with a tendency toward osteoporosis).


Detoxifying

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Silicon-containing compounds play an important protective role in the body, enhancing its self-defense functions and its detoxification capacity. This is partly because silicon compounds facilitate the elimination through urine of metabolites and foreign or toxic derivatives, and act as a barrier, slowing the progression of degenerative processes and increasing collagen biosynthesis.


Safe dosage

Adult: 20 mg - 50 mg

EFSA (European Food Safety Authority), the European Food Safety Authority, issued a favorable scientific opinion in January 2009 on "orthosilicic acid stabilized with choline for nutritional purposes in food supplements". The scientific panel determined that the element silicon is fully bioavailable from choline-stabilized orthosilicic acid and that its use in food supplements poses no toxicological concerns. To date, no nutrient reference value (NRV) has been established in Europe. However, "EFSA estimated that the typical dietary intake of silicon is 20-50 mg/day, which corresponds to 0.3-0.8 mg of silicon/kg body weight per day for a 60 kg person, and concluded that such intakes are unlikely to have harmful effects". According to silicon toxicity studies, the lethal dose is greater than 5 g/kg body weight, which is more than 1,000 times higher than the dose beneficial to the human body.


Precautions

Pregnant women: avoid

There is not enough reliable information available on the safety of silicon when it is used at medicinal doses.

Breastfeeding women: avoid

There is not enough reliable information available on the safety of silicon when it is used at medicinal doses.