Silver: Benefits, Dosage, Contraindications

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Silver has been known since antiquity for its anti-inflammatory, anti-infective, and healing properties, and was used to purify water and preserve food. Its medical use has diversified over the centuries, integrating water purification, wound care, and medical devices. Silver ions, released in the presence of water or body fluids, possess biological activity that allows them to interact effectively with the cell membranes of bacteria and fungi, thus blocking their multiplication and function. Silver is not an essential nutrient. It is naturally present in some foods, such as vegetables, fruits, and cereals. In modern medicine, silver is used in various forms, such as colloidal silver or silver sulfadiazine, to treat infections and prevent biofilm formation in medical devices. However, excessive use in large doses has sometimes led to a condition known as argyria, which gives a grayish appearance to the body. The quantities offered in local-use preparations do not present this type of risk and silver remains an effective treatment for nasal mucous membrane conditions.

Other name(s) 

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Scientific name(s)

silver

Family or group: 

Minerals and Trace Elements


Indications

Rating methodology

EFSA approval.

Several clinical trials (> 2) randomized controlled with double blind, including a significant number of patients (>100) with consistently positive outcomes for the indication.
Several clinical trials (> 2) randomized controlled with double blind, and including a significant number of patients (>100) with positive outcomes for the indication.
One or more randomized studies or multiple cohorts or epidemiological studies with positive outcomes for the indication.
Clinical studies exist but are uncontrolled, with conclusions that may be positive or contradictory.
Lack of clinical studies to date that can demonstrate the indication.


Mouth Ulcers
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Silver nitrate is widely used to treat mouth ulcers due to its antiseptic and healing properties. Regular use of silver nitrate can reduce inflammation associated with ulcers, speed up their healing, and prevent infections.

Posologie

posologieOral route


Wound
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Silver can be used in various forms, including silver-based dressings. These dressings release silver ions in a controlled manner, ensuring prolonged action in contact with the wound.

Posologie

posologieCutaneous route


Properties


Antibacterial

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Laboratory research shows that preparations containing silver nanoparticles exhibit activity against Gram-negative and Gram-positive bacteria, including Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Bacillus anthracis, Acinetobacter baylyi, Escherichia coli, Proteus mirabilis, Micrococcus luteus, Pseudomonas putida, Pseudomonas aeruginosa, Klebsiella pneumoniae, Citrobacter, and Shigella dysenteriae type I.


Antiviral

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In vitro research shows that colloidal silver has antiviral activity against the poxvirus.

Usages associés

Flu

Healing

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Silver has several healing properties. Firstly, it has strong antimicrobial properties, reducing the risk of infection and promoting a healing-friendly environment. Additionally, silver has an anti-inflammatory role by reducing local inflammation, which helps accelerate the healing process. Finally, it promotes tissue regeneration by stimulating cell proliferation and facilitating the formation of quality scar tissue.

Usages associés

Wound, Mouth Ulcers

Anti-inflammatory

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Various in vitro studies have shown that silver can decrease the expression of certain inflammatory mediators, such as pro-inflammatory cytokines. It can also inhibit the activation of inflammatory cells.


Anticancer

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In vitro research shows that silver nanoparticles are active against human breast cancer cells, human colorectal epithelial adenocarcinoma cells, and human hepatocellular carcinoma cells.


Safety dosage


Plantes ou autres actifs

Silver: low interaction

Theoretically, silver could reduce iodine absorption.

Precautions

Adult: use with caution

The total daily intake of silver should not exceed 14 mcg/kg per day. Combining silver supplements with regular dietary silver intake would likely exceed this amount. Colloidal silver: 20 ppm.