SOD: benefits, dosage, contraindications
Other name(s)
Superoxide Dismutase
Scientific name(s)
Superoxide Dismutase
Family or group:
Enzymes
Indications
Rating methodology
EFSA approval.
UV exposure ✪✪✪✪✪
SOD protects against premature skin aging related to UV-induced photo-oxidative reactions. These photo-oxidative reactions activate matrix metalloproteinases that degrade extracellular matrix proteins, notably collagen.
Posologie
Oral route
500 - 500 mg
2 - months
Adults
melon extract
Fatigue ✪✪✪✪✪
A pistil pollen extract rich in SOD reduces lactic acid production in muscles and decreases muscle fatigue during exertion.
Posologie
Oral route
136 - 272 mg
Adults
pistil pollen extract
Stress ✪✪✪✪✪
Clinical research shows that taking a specific melon extract providing 140 IU of superoxide dismutase daily for 84 days slightly reduces stress in healthy patients.
Posologie
Oral route
140 IU
melon extract
Oxidative stress ✪✪✪✪✪
Superoxide dismutase is an essential enzyme present in all living cells. Certain cellular processes produce reactive oxygen species, such as superoxide radicals, which can impair cellular function. Superoxide dismutase catalyzes the conversion of superoxide into oxygen and hydrogen peroxide, thereby reducing the damage caused by reactive oxygen species.
Posologie
Oral route
10 - 20 mg
Healthy aging ✪✪✪✪✪
SOD is considered an anti-aging enzyme. Oxygen free radicals generated in metabolic pathways lead to age-related deterioration through oxidative damage to biomolecules, with mitochondria being the main target of attack. The accumulation of oxidative damages is considered one of the main mechanisms of aging. It has been suggested that novel SOD mimetics could be useful in mitigating aging-induced cognitive deficits and other aspects of physiological decline with aging.
Posologie
Oral route
10 - 20 mg
Properties
Antioxidant
Superoxide dismutase is an essential enzyme present in all living cells. Certain cellular processes produce reactive oxygen species, such as superoxide radicals, which can impair cellular function. Superoxide dismutase catalyzes the conversion of superoxide into oxygen and hydrogen peroxide, thereby reducing the damage caused by reactive oxygen species.
Usages associés
Anti-inflammatory
SOD can serve as an inhibitor of neutrophil-mediated inflammation and could represent a novel therapeutic approach for ROS-dependent tissue injuries induced by neutrophils through various mechanisms. Preclinical studies have provided encouraging results for its use as a human therapeutic agent in acute and chronic inflammatory conditions. Mn-SOD, extracellular Mn-SOD, and Cu, Zn-SOD have been described as potential inflammation inhibitors.
Anti-aging
SOD is considered an anti-aging enzyme. Oxygen free radicals generated in metabolic pathways lead to age-related deterioration through oxidative damage to biomolecules, with mitochondria being the main target of attack. The accumulation of oxidative damages is considered one of the main mechanisms of aging. It has been suggested that novel SOD mimetics could be useful in mitigating aging-induced cognitive deficits and other aspects of physiological decline with aging.
Usages associés
Immunostimulant
Superoxide dismutase strengthens the body's natural defenses against excessive free radicals and helps maintain the immune system.
Safety dosage
Adult: 500 mg - 500 mg (melon extract)
SOD is safe when used orally in an appropriate manner. A dose of 500 mg of melon extract, equivalent to 500 IU of SOD, is used for 1 to 2 months.
Precautions
Pregnant women: avoid
Avoid use in pregnant women due to lack of reliable and sufficient information.
Breastfeeding women: avoid
Avoid use in breastfeeding women due to lack of reliable and sufficient information.
