Ursolic acid: Benefits, Dosage, Contraindications
Other name(s)
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Scientific name(s)
UA
Family or group:
Phytosubstances
Indications
Rating methodology
EFSA approval.
Sport performance ✪✪✪✪✪
An increase in IRSINE levels, thought to be involved in the physiology of skeletal muscles, was observed in a clinical study among athletes to measure muscle strength following ursolic acid supplementation. In a clinical study, combining ursolic acid supplementation (450 mg/day) with resistance training over 8 weeks increased muscle strength and IGF-1 (insulin-like growth factor) levels compared to training alone, although the authors did not observe significant gains in lean body mass, meaning the body's mass without fat.
Posologie
Orally
450 mg
Adults
dry extract
Muscle Dystrophy ✪✪✪✪✪
Research has proven that ursolic acid could be a therapeutic intervention against muscle atrophy and dysfunction induced by aging. It also significantly improved skeletal muscle mass and grip strength in rodents. A similar study revealed that ursolic acid increased satellite cell numbers and activated myoglobin expression in aged mice, suggesting it positively altered skeletal muscle rejuvenation by stimulating protein synthesis and suppressing atrophy factors. Other studies reported that ursolic acid improved skeletal muscle atrophy by inhibiting pathways associated with muscle atrophy. These include the muscle protein 1 (MuRF-1) and atrogin-1 pathways, two essential mediators of protein degradation in skeletal muscles. It was also shown that ursolic acid increased skeletal muscle hypertrophy by increasing insulin-like growth factor 1 (IGF-1) secretion. Finally, it was demonstrated that a 12-week treatment with ursolic acid improves skeletal muscle strength and mass in a dose-dependent manner via upregulation of the Akt/mammalian target of rapamycin (mTOR) signaling pathway and downregulation of skeletal muscle atrophy parameters, such as Atrogin-1 and MuRF-1.
Posologie
Orally
400 mg
7 - days
Seniors
dry extract
Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy
Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease.
Ursolic acid in health and disease
Ursolic acid ameliorates aging-metabolic phenotype through promoting of skeletal muscle rejuvenation.
Apple Pomace Extract Improves Endurance in Exercise Performance by Increasing Strength and Weight of Skeletal Muscle.
mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass.
Weight Control ✪✪✪✪✪
According to a study, ursolic acid at 100 mg/kg in rats seems to attenuate the increase in triglycerides in response to a fatty meal, presumed to occur by inhibiting pancreatic lipase. An equivalent dosage in humans is estimated at 160 mg/kg.
Posologie
Orally
160 mg
12 - weeks
Adults
dry extract
Properties
Metabolic
In an in-vivo study, ursolic acid was reported to reduce adipocyte growth while stimulating fat burning. Researchers observed that it increases energy consumption (thermogenesis) by promoting the growth of brown adipose tissue and inhibiting white adipose tissue growth. Therefore, dietary supplementation with ursolic acid appears capable of inhibiting body weight gain in the mice studied. However, further research is needed to confirm this hypothesis.
Usages associés
Anticancer
Ursolic acid exerts most of its anticancer effects through apoptosis regulation, leading to reduced proliferation and angiogenesis, thus preventing tumor formation and metastases.
Anti-inflammatory
Ursolic acid has an anti-inflammatory effect by inhibiting 5-lipoxygenase and COX-2.
Safety dosage
Adult from 18 years old: 150 mg - 450 mg
