White Mulberry: Benefits, Dosage, Contraindications

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The White Mulberry, native to China, is a leafy tree belonging to the Moraceae family. Known for its leaves nourishing silkworms, this tree also has a long history of use in traditional Chinese, Japanese, and Korean medicine. In France, the first evidence of mulberry cultivation dates back to the Roman era, as evidenced by the discovery of mulberry seeds in various sites, mainly in southern France and Mediterranean regions. Its fruits, leaves, and even its bark are rich in active components such as anthocyanins, flavonoids, and other polyphenols, which confer interesting medicinal properties. Nevertheless, it's the leaves that are used therapeutically. In ancient societies, its leaves were used for their antioxidant and hypotensive properties, a use documented in several ancient texts and corroborated by contemporary analyses. From a scientific perspective, studies highlight the antioxidant, anti-inflammatory, and antidiabetic properties of the white mulberry. These effects are attributed to key compounds such as 1-Deoxynojirimycin and its derivatives present in the leaves. Thanks to these properties, the white mulberry is a potential ally in managing chronic diseases like type 2 diabetes.

Other name(s) 

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Scientific name(s)

Morus Alba, Morus indica

Family or group: 

Plants

Active ingredients:

1-Deoxynojirimycin


Indications

Rating methodology

EFSA approval.

Several clinical trials (> 2) randomized controlled with double blind, including a significant number of patients (>100) with consistently positive outcomes for the indication.
Several clinical trials (> 2) randomized controlled with double blind, and including a significant number of patients (>100) with positive outcomes for the indication.
One or more randomized studies or multiple cohorts or epidemiological studies with positive outcomes for the indication.
Clinical studies exist but are uncontrolled, with conclusions that may be positive or contradictory.
Lack of clinical studies to date that can demonstrate the indication.


Type 2 Diabetes
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White Mulberry demonstrates variable efficacy on type 2 diabetes. A meta-analysis of 4 clinical studies (12 weeks) concludes a modest improvement in glucose tolerance without impact on HbA1c, glycated hemoglobin biological marker of long-term glycemic control. The studied doses range from 500 mg to 4.6 g per day, containing 5-18 mg of deoxynojirimycin.

Posologie

posologieOral: leaf

posologie500 mg

duration4 - weeks

formulationstandardized extract


Metabolic Syndrome
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White Mulberry seems to have promising effects on certain aspects of metabolic syndrome, although the evidence is limited. A clinical study shows that supplementation with white mulberry extract (300 mg twice daily for 12 weeks) modestly improves lipid profiles, with a decrease in total cholesterol and LDL. In obese patients with prediabetes, taking 4.6 g three times a day for 12 weeks slightly reduces fasting glucose and HbA1c. Finally, in overweight adults following a low-calorie diet, a white mulberry extract (800 mg three times a day for 90 days) results in significant weight loss of 10%.

Posologie

posologieOral: leaf

posologie600 mg

formulationstandardized extract


Properties


Hypoglycemic

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White Mulberry is recognized for its hypoglycemic properties, primarily attributed to the presence of bioactive compounds such as 1-Deoxynojirimycin, a potent alpha-glucosidase inhibitor. This enzyme, involved in carbohydrate digestion, plays a key role in the release of glucose after a meal. By blocking its action, 1-Deoxynojirimycin slows glucose absorption, reducing postprandial glucose spikes. Clinical studies support this effect. Additionally, the antioxidant and anti-inflammatory compounds present in the mulberry, such as flavonoids and anthocyanins, help reduce oxidative stress and chronic inflammation associated with diabetes. This could also play a protective role against cardiovascular and nerve complications linked to the disease.

Usages associés

Type 2 Diabetes

Metabolic

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Studies on mice fed a high-fat diet show that the addition of white mulberry fruit powder or polysaccharides extracted from the leaves significantly improves glucose tolerance. These compounds alleviate body fat accumulation and weight gain while reducing blood LDL cholesterol levels. This dual effect on carbohydrate and lipid metabolism suggests an important role in preventing metabolic syndrome. White Mulberry could act in weight management. Deoxynojirimycin inhibits the alpha-glucosidase enzymes in the intestine, thus delaying polysaccharide absorption and limiting postprandial glucose spikes. Furthermore, the leaf polysaccharides inhibit pancreatic lipase, the key enzyme in dietary fat absorption. This dual action slows the absorption of energy macronutrients and promotes weight control.

Usages associés

Metabolic Syndrome


Safety dosage

Adult : 500 mg - 3000 mg

White mulberry leaf powder or extract: generally administered at 0.5 to 1 g three times per day, for a maximum duration of 3 months. Standardized products: Leaf powder standardized to 1.5% 1-Deoxynojirimycin.


Precautions

Pregnant women: avoid

Insufficient data to ensure safety; avoid use unless under medical supervision.

Breastfeeding women: avoid

Insufficient data to ensure safety; avoid use unless under medical supervision.