White Mulberry: Benefits, Dosage, Contraindications
Other name(s)
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Scientific name(s)
Morus Alba, Morus indica
Family or group:
Plants
Active ingredients:
1-Deoxynojirimycin
Indications
Rating methodology
EFSA approval.
Type 2 Diabetes ✪✪✪✪✪
White Mulberry demonstrates variable efficacy on type 2 diabetes. A meta-analysis of 4 clinical studies (12 weeks) concludes a modest improvement in glucose tolerance without impact on HbA1c, glycated hemoglobin biological marker of long-term glycemic control. The studied doses range from 500 mg to 4.6 g per day, containing 5-18 mg of deoxynojirimycin.
Posologie
Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomized, double blind, placebo-controlled study
Morus Alba leaf extract affects metabolic profiles, biomarkers inflammation and oxidative stress in patients with type 2 diabetes mellitus: A double-blind clinical trial
Morus alba L. for Blood Sugar Management: A Systematic Review and Meta-Analysis
Metabolic Syndrome ✪✪✪✪✪
White Mulberry seems to have promising effects on certain aspects of metabolic syndrome, although the evidence is limited. A clinical study shows that supplementation with white mulberry extract (300 mg twice daily for 12 weeks) modestly improves lipid profiles, with a decrease in total cholesterol and LDL. In obese patients with prediabetes, taking 4.6 g three times a day for 12 weeks slightly reduces fasting glucose and HbA1c. Finally, in overweight adults following a low-calorie diet, a white mulberry extract (800 mg three times a day for 90 days) results in significant weight loss of 10%.
Posologie
Morus Alba leaf extract affects metabolic profiles, biomarkers inflammation and oxidative stress in patients with type 2 diabetes mellitus: A double-blind clinical trial
White mulberry supplementation as adjuvant treatment of obesity
Properties
Hypoglycemic
White Mulberry is recognized for its hypoglycemic properties, primarily attributed to the presence of bioactive compounds such as 1-Deoxynojirimycin, a potent alpha-glucosidase inhibitor. This enzyme, involved in carbohydrate digestion, plays a key role in the release of glucose after a meal. By blocking its action, 1-Deoxynojirimycin slows glucose absorption, reducing postprandial glucose spikes. Clinical studies support this effect. Additionally, the antioxidant and anti-inflammatory compounds present in the mulberry, such as flavonoids and anthocyanins, help reduce oxidative stress and chronic inflammation associated with diabetes. This could also play a protective role against cardiovascular and nerve complications linked to the disease.
Usages associés
Metabolic
Studies on mice fed a high-fat diet show that the addition of white mulberry fruit powder or polysaccharides extracted from the leaves significantly improves glucose tolerance. These compounds alleviate body fat accumulation and weight gain while reducing blood LDL cholesterol levels. This dual effect on carbohydrate and lipid metabolism suggests an important role in preventing metabolic syndrome. White Mulberry could act in weight management. Deoxynojirimycin inhibits the alpha-glucosidase enzymes in the intestine, thus delaying polysaccharide absorption and limiting postprandial glucose spikes. Furthermore, the leaf polysaccharides inhibit pancreatic lipase, the key enzyme in dietary fat absorption. This dual action slows the absorption of energy macronutrients and promotes weight control.
Usages associés
Safety dosage
Adult : 500 mg - 3000 mg
White mulberry leaf powder or extract: generally administered at 0.5 to 1 g three times per day, for a maximum duration of 3 months. Standardized products: Leaf powder standardized to 1.5% 1-Deoxynojirimycin.
Precautions
Pregnant women: avoid
Insufficient data to ensure safety; avoid use unless under medical supervision.
Breastfeeding women: avoid
Insufficient data to ensure safety; avoid use unless under medical supervision.