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What are the side effects and contraindications of GABA?

Doctorante en Pharmacie

Taking GABA dietary supplements is known for its anxiolytic properties, anti-stress benefits, and positive impact on sleep quality. But what are its side effects and contraindications?

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GABA, gamma-aminobutyric acid, is a neurotransmitter found in the body. It plays an important role in brain activity and the nervous system.

Parmi ses actions, il se fixe sur des récepteurs inhibiteurs du cerveau (récepteurs GABAA et GABAB) and contributes to the regulation of mood, stress, anxiety, and even insomnia phenomena. Its presence induces a state of relaxation and general calmness. 

In fact, many therapies for anxiety and sleep disorders, such as benzodiazepines (Alprazolam) and zolpidem, work by binding to the same receptors as GABA. 

GABA is directly secreted by the body from glutamine or glutamate, but can also be sourced from food, or dietary supplements. It is notably found in nuts, bananas, citrus fruits, and certain green vegetables. 

📚 Also read | 10 natural anxiolytics for stress and anxiety

In case of misuse and overdose

Taking GABA is generally safe for the healthy general population. It must still be consumed properly!

Its misuse, or an overdose could lead to side effects. You may experience: 

  • feel skin tingling, or have redness on the skin
  • feel shortness of breath
  • experience some digestive issues, such as nausea or abdominal pain
  • feel fatigue or suffer from drowsiness
  • experience dizziness and headaches

If any of these symptoms appear, stop taking GABA immediately and consult your doctor.

Contraindications to respect

Since GABA interacts with the central nervous system, it is contraindicated in certain situations. This is especially true if: 

  • you are taking a sedative, anxiolytic, or antidepressant of the SSRI class to avoid drug interactions
  • you have blood pressure issues regulated by medication
  • you have a history of seizures
  • if you are pregnant : GABA intake has not been sufficiently tested
  • if you are breastfeeding, to avoid passage into breast milk
  • in children
  • In case of hypersensitivity to the molecule